Validation of a Noninvasive Measurement of Regional Hemoglobin Oxygen Saturation
Near-infrared (NIR) spectroscopy may provide a continuous and noninvasive assessment of global brain hemoglobin oxygen saturation by measuring the differential absorption of infrared light [1–3]. As biological tissues are relatively transparent to infrared light at wavelengths between 400 and 1000 nm, infrared light may penetrate skin, subcutaneous tissue, bone, and dura to the brain [4–7], where it is absorbed by oxygenated hemoglobin, deoxygenated hemoglobin, and cytochrome aa3. Thus, the attenuation of infrared light of specific wavelengths by these chromophores may be used to measure brain oxygenation [1, 3, 8–11]. The hemoglobin oxygen saturation measured by the cerebral oximeter receives contributions from arterial, venous, and capillary blood vessels, with a predominantly venous contribution [11, 12], and may reflect the balance between cerebral oxygen consumption and delivery.
KeywordsInfrared Light Hemoglobin Oxygen Saturation Cerebral Oximetry Pulse Oximeter Reading Cerebral Oximeter
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