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Glutamate Neurotoxicity As a Mechanism of Ischemic Brain Damage: A Basic Study Using a New In Vivo Model

  • Hirosuke Fujisawa
  • Hans Landolt
  • Ross Bullock

Abstract

Ischemic brain damage is seen as a common feature in many pathological conditions such as ischemic stroke, subarachnoid hemorrhage, head injury, and prolonged seizures [1]. A number of animal studies have shown that there is a marked increase in the extracellular concentrations of glutamate under such conditions [2–7]. The neuroprotective effects of glutamate antagonists have also been demonstrated in the animal models of ischemia and head injury [1, 8], and thus it has been suggested that these conditions share a common injury mechanism, that is, glutamate neurotoxicity.

Keywords

Glutamate Uptake Glutamate Concentration Microdialysis Probe Ischemic Brain Damage Glutamate Neurotoxicity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1995

Authors and Affiliations

  • Hirosuke Fujisawa
    • 1
  • Hans Landolt
    • 2
  • Ross Bullock
    • 3
  1. 1.Department of NeurosurgeryYamaguchi University School of MedicineUbe, YamaguchiJapan
  2. 2.Kantonsspital AarauNeurochirurgische UniversitätsklinikAarauSchweiz
  3. 3.Division of Neurosurgery, Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA

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