Glutamate Neurotoxicity As a Mechanism of Ischemic Brain Damage: A Basic Study Using a New In Vivo Model
Ischemic brain damage is seen as a common feature in many pathological conditions such as ischemic stroke, subarachnoid hemorrhage, head injury, and prolonged seizures . A number of animal studies have shown that there is a marked increase in the extracellular concentrations of glutamate under such conditions [2–7]. The neuroprotective effects of glutamate antagonists have also been demonstrated in the animal models of ischemia and head injury [1, 8], and thus it has been suggested that these conditions share a common injury mechanism, that is, glutamate neurotoxicity.
KeywordsGlutamate Uptake Glutamate Concentration Microdialysis Probe Ischemic Brain Damage Glutamate Neurotoxicity
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