Glutamate Neurotoxicity As a Mechanism of Ischemic Brain Damage: A Basic Study Using a New In Vivo Model

  • Hirosuke Fujisawa
  • Hans Landolt
  • Ross Bullock


Ischemic brain damage is seen as a common feature in many pathological conditions such as ischemic stroke, subarachnoid hemorrhage, head injury, and prolonged seizures [1]. A number of animal studies have shown that there is a marked increase in the extracellular concentrations of glutamate under such conditions [2–7]. The neuroprotective effects of glutamate antagonists have also been demonstrated in the animal models of ischemia and head injury [1, 8], and thus it has been suggested that these conditions share a common injury mechanism, that is, glutamate neurotoxicity.


Glutamate Uptake Glutamate Concentration Microdialysis Probe Ischemic Brain Damage Glutamate Neurotoxicity 
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Copyright information

© Springer-Verlag Tokyo 1995

Authors and Affiliations

  • Hirosuke Fujisawa
    • 1
  • Hans Landolt
    • 2
  • Ross Bullock
    • 3
  1. 1.Department of NeurosurgeryYamaguchi University School of MedicineUbe, YamaguchiJapan
  2. 2.Kantonsspital AarauNeurochirurgische UniversitätsklinikAarauSchweiz
  3. 3.Division of Neurosurgery, Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA

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