Skip to main content
SpringerLink
Log in

Depression in HIV-Infected Adults: Newer Concepts

  • Conference paper
Current Perspectives and Future Directions in Palliative Medicine

  • 68 Accesses

Summary

HIV infection is commonly accompanied by clinical or subclinical neurological involvement. Thus, it is not surprising that psychological and psychiatric complications of disease are commonly seen. While suicidality is perhaps less commonly seen than initially thought, depressive symptomatology is common in adults with HIV infection and reflects a complex interplay between biological, psychological, and social factors. Depression accounts for a significant proportion of somatic symptoms in individuals with early HIV infection, but is most prevalent in people with progressive disease and those who are most disenfranchised. Fortunately, a variety of antidepressants has been demonstrated to ameliorate depressive symptoms in this population, although HIV-infected persons are at higher risk of adverse effects from psychoactive medications. During the past several years, advances in antiretroviral therapy have markedly improved the long term prognosis of HIV disease. These developments have altered the perception of this illness as an invariably terminal disease, but have created new concerns and questions for infected individuals that may cause more short term psychological distress.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Katz MH, Douglas JM, Bolan GA, et al. Depression and use of mental health services among HIV-infected men. AIDS Care, 1996, 8:433–42.

    Article  PubMed  CAS  Google Scholar 

  2. Judd FK, Mijch AM. Depressive symptoms in patients with HIV infection. Aust New Zeal J Psych, 1996, 30:104–9.

    Article  CAS  Google Scholar 

  3. Perkins DO, Stern RA, Golden RN, et al. Mood disorders in HIV infection: prevalence and risk factors in a nonepicenter of the AIDS epidemic. Am J Psych, 1994, 151:233–6.

    CAS  Google Scholar 

  4. Rabkin JG, Ferrando SJ, Jacobsberg LB, Fishman B. Prevalence of axis I disorders in an AIDS cohort: a cross-sectional, controlled study. Comp Psych, 1997, 38:146–54.

    Article  CAS  Google Scholar 

  5. Lipsitz JD, Williams JB, Rabkin JG, et al. Psychopathology in male and female intravenous drug user with and without HIV infection. Am J Psych, 1994, 151:1662–8.

    CAS  Google Scholar 

  6. Maj M, Janssen R, Starace F, et al. WHO neuropsychiatrie AIDS study, cross-sectional phase I. Study design and psychiatric findings. Arch Gen Psych, 1994, 51:39–49.

    Article  CAS  Google Scholar 

  7. Perkins DO, Lesserman J, Stern RA, et al. Somatic symptoms and HIV infection: relationship to depressive symptoms and indicators of HIV disease. Am J Psych, 1995, 152:1776–81.

    CAS  Google Scholar 

  8. O’Dell MW, Meighen M, Riggs RV. Correlates of fatigue in HIV infection prior to AIDS: a pilot study. Disability Rehab, 1996, 18:249–54.

    Article  Google Scholar 

  9. Rabkin JG, Goetz RR, Remien RH, et al. Stability of mood despite HIV illness progression in a group of homosexual men. Am J Psych, 1997, 154:231–8.

    CAS  Google Scholar 

  10. Lyketsos CG, Hoover DR, Guccione M, et al. Changes in depressive symptoms as AIDS develops. The Multicenter AIDS Cohort Study. Am J Psych, 1996, 153:1430–7.

    CAS  Google Scholar 

  11. Lyketsos CG, Hutton H, Fishman M, Schwartz J, Treisman GJ. Psychiatric morbidity on entry to an HIV primary care clinic. AIDS, 1996, 10:1033–9.

    Article  PubMed  CAS  Google Scholar 

  12. Johnson JG, Williams JB, Rabkin JG, Goetz RR, Remien RH. Axis I psychiatric symptoms associated with HIV infection and personality disorder. Am J Psych, 1995, 152:551–4.

    CAS  Google Scholar 

  13. Fukunishi I, Hosaka T, Negishi M, et al. Subclinical depressive symptoms in HIV are related to avoidance coping responses: a comparison with end-stage renal failure and breast cancer. Psych Reports, 1996, 78:483–8.

    Article  CAS  Google Scholar 

  14. Fukunishi I, Hayashi M, Matsumoto T, et al. Liaison psychiatry and HIV infection (1): avoidance coping responses associated with depressive symptoms accompanying somatic complaints. Psych and Clin Neurosciences, 1997, 51:1–4.

    Article  CAS  Google Scholar 

  15. Fukunishi I, Hosaka T, Negishi M, et al. Avoidance coping behaviors and low social support are related to depressive symptoms in HIV-positive patients in Japan. Psychosomatics, 1997, 38:113–8.

    Article  PubMed  CAS  Google Scholar 

  16. Maj M. Depressive syndromes and symptoms in subjects with human immunodeficiency virus (HIV) infection. Br J Psych, 1996, Suppl:117–22.

    Google Scholar 

  17. McClure JB, Catz SL, Prejean J, Brantley PJ, Jones GN. Factors associated with depression in a heterogeneous HIV-infected sample. J Psychosomatic Res, 1996, 40:407–15.

    Article  CAS  Google Scholar 

  18. Rosenfeld B, Breitbart W, McDonald MV, et al. Pain in ambulatory AIDS patients. II. Impact of pain on psychological functioning and quality of life. Pain, 1996, 68:323–8.

    Article  PubMed  CAS  Google Scholar 

  19. O’Dowd MA, Biderman DJ, McKegney FP. Incidence of suicidality in AIDS and HIV-positive patients attending a psychiatry outpatient program. Psychosomatics, 1993, 34:33–40.

    Article  PubMed  Google Scholar 

  20. Ndimbie OK, Perper JA, Kingsley L, Harty L, Winkelstein A. Sudden unexpected death in a male homosexual cohort. Am J Forensic Med Path, 1994, 15:247–50.

    Article  CAS  Google Scholar 

  21. Dannenberg AL, McNeil JG, Brundage JF, Brookmeyer R. Suicide and HIV infection. Mortality follow-up of 4147 HIV-seropositive military service recruits. JAMA, 1996, 276:1743–6.

    Article  PubMed  CAS  Google Scholar 

  22. Rabkin JG, Rabkin R, Harrison W, Wagner G. Effect of imipramine on mood and enumerative measures of immune status in depressed patinets with HIV illness. Am J Psych, 1994, 151:516–23.

    CAS  Google Scholar 

  23. Grassi B, Gambini O, Garghentini G, Lazzarin A, Scarone S. Efficacy of paroxetine for the treatment of depression in the context of HIV infection. Pharmacopsych, 1997, 30:70–1.

    Article  CAS  Google Scholar 

  24. Ferrando SJ, Goldman JD, Charness WE. Selective serotonin reuptake inhibitor treatment of depression in symptomatic HIV infection and AIDS. Improvements in affective and somatic symptoms. Gen Hosp Psych, 1997, 19:89–97.

    Article  CAS  Google Scholar 

  25. Wagner GJ, Rabkin JG, Rabkin R. Dextroamphetamine as a treatment for depression and low enegy in AIDS patients: a pilot study. J Psychosom Res, 1997, 42:407–11.

    Article  PubMed  CAS  Google Scholar 

  26. Wagner GJ, Rabkin JG, Rabkin R. A comparative analysis of standard and alternative antidepressants in the treatment of human immunodeficiency virus patients. Comp Psych, 1996, 37:402–8.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Categorical Residency Program, Department of Medicine, University of California, San Francisco, CA, 94143, USA

    Harry Hollander M.D. (Professor of Clinical Medicine, Director)

Authors
  1. Harry Hollander M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. National Shikoku Cancer Center, 13 Horinouchi, Matsuyama, Ehime, 790-8501, Japan

    Kenji Eguchi (Vice Director) (Vice Director)

  2. Institut Jules Bordet, Centre des Tumeurs de l’Université Libre de Bruxelles, Bruxelles, Rue Héger-Bordet 1, 1000, Bruxelles, Belgique

    Jean Klastersky (Professor and Chief of Medicine) (Professor and Chief of Medicine)

  3. Ontario Cancer Institute/Princess Margaret Hospital, 610 University Ave., Toronto, Ontario, M5G 2M9, Canada

    Ronald Feld (Professor of Medicine) (Professor of Medicine)

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer-Verlag Tokyo

About this paper

Cite this paper

Hollander, H. (1998). Depression in HIV-Infected Adults: Newer Concepts. In: Eguchi, K., Klastersky, J., Feld, R. (eds) Current Perspectives and Future Directions in Palliative Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68494-7_8

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-68494-7_8

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68496-1

  • Online ISBN: 978-4-431-68494-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation