Abstract
Interferon (IFN) therapy has been shown to be efficacious in some patients with chronic hepatitis C [1–4]. In responders, normal alanine aminotransferase (ALT) levels and disappearance of hepatitis C virus (HCV) from serum continues for several years and probably permanently after IFN. Such a response is called sustained response, and has been thought to benefit the prognosis of the patients.
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References
Davis GL, Baklart LA, Schiff ER, et al (1989) Treatment of chronic hepatitis C with recombinant interferon alpha. A multicenter randomized, controlled trial. N Engl J Med 321:1501–1506
Di Bisceglie AM, Martin P, Kassianides C, et al (1989) Recombinant interferon alpha therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial. N Engl J Med 321:1506–1510
Marcellin P, Boyer N, Giostra E, et al (1991) Recombinant human alpha-interferon in patients with chronic non-A, non-B hepatitis: a multicenter randomized controlled trial from France. Hepatology 13:393–397
Pagliaro L, Craxi A, Cammaa C, et al (1994) Interferon-alpha for chronic hepatitis C: an analysis of pretreatment clinical predictors of response. Hepatology 19:820–828
Chemello L, Bonetti P, Cavalletto L, et al (1995) Randomized trial comparing three different regimens of alpha-2a-interferon in chronic hepatitis C. Hepatology 22:700–706
Shiratori Y, Kato N, Yokosuka O, et al (1997) Predictors of the efficacy of interferon therapy in chronic hepatitis C virus infection. Gastroenterology 113:558–566
Desmet VJ, Gerber M, Hoofnagle JH, et al (1994) Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 19:1513–1520
Tanaka T, Tsukiyama-Kohara K, Yamaguchi K, et al (1994) Significance of specific antibody assay for genotyping of hepatitis C virus. Hepatology 19:1347–1353
Simmonds P, McOmish F, Yap PL, et al (1993) Sequence variability in the 5′ non-coding region of hepatitis C virus: identification of a new virus type and restrictions on sequence diversity. J Gen Virol 74:661–668
Urdea MS, Horn T, Fultz TJ, et al (1991) Branched DNA amplification multimers for the sensitive, direct detection of human hepatitis viruses. Nucleic Acids Symp Ser 24:197–200
Lau JYN, Davis GL, Kniffen J, et al (1993) Significance of serum hepatitis C virus RNA levels in chronic hepatitis C. Lancet 341:1501–1504
Yoshioka K, Higashi Y, Yamada M, et al (1995) Predictive factors in the response to interferon therapy in chronic hepatitis C. Liver 15:57–62
Yoshioka K, Kakumu S, Wakita T, et al (1992) Detection of hepatitis C virus by polymerase chain reaction and response to interferon-alpha therapy: relationship to genotypes of hepatitis C virus. Hepatology 16:293–299
Hino K, Okuda M, Konishi T, et al (1995) Serial assay of hepatitis C virus RNA in serum for predicting response to interferon-alpha therapy. Dig Dis Sci 40:14–20
Orito E, Mizokami M, Suzuki K, et al (1995) Loss of serum HCV RNA at week 4 of interferon-alpha therapy is associated with more favorable long-term response in patients with chronic hepatitis C. J Med Virol 46:109–115
Kakumu S, Aiyama T, Okumura A, et al (1997) Earlier loss of hepatitis C virus RNA in interferon therapy can predict a long-term response in chronic hepatitis C. J Gastroenterol Hepatol 12:468–472
Sharara AI, Hunt CM, Hamilton JD (1996) Hepatitis C. Ann Intern Med 125:658–668
Kakumu S, Yoshioka K, Tanaka K, et al (1993) Long-term carrier state of hepatitis C virus with normal aminotransferase after interferon treatment in patients with chronic hepatitis C. J Med Virol 41:65–70
Lau JY, Mizokami M, Ohno T, et al (1993) Discrepancy between biochemical and virological responses to interferon-alpha in chronic hepatitis C. Lancet 342:1208–1209
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© 1999 Springer-Verlag Tokyo
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Kakumu, S., IFN Treatment Group of Affiliated Hospitals of the Third Department of Internal Medicine. (1999). Randomized Controlled Trial of Lymphoblastoid Interferon-α for Chronic Hepatitis C; Early Disappearance of HCV RNA is Essential for Sustained Response. In: Okita, K. (eds) HCV and Related Liver Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68488-6_7
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DOI: https://doi.org/10.1007/978-4-431-68488-6_7
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68490-9
Online ISBN: 978-4-431-68488-6
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