Mutation Pattern of Hepatitis C Virus and Its Application to Therapy
Chronic hepatitis C is a common disease worldwide and is a major cause of chronic liver disease in many countries. However, the current standard therapy of chronic hepatitis C with interferon (IFN) is rather unsatisfactory [1–3]. Therefore, the search for additional therapies needs to be pursued. Molecular evolutionary analysis has been applied to numerous studies of hepatitis C virus (HCV) and has given many informative suggestions. However, it has not yielded helpful information for developing effective antiviral drugs against chronic HCV infection.
KeywordsSubstitution Pattern Mutation Pattern Human Immunodeficiency Virus Replication Full Code Region Nucleotide Substitution Pattern
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