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Mutation Pattern of Hepatitis C Virus and Its Application to Therapy

  • Masashi Mizokami
  • Tatsunori Nakano
  • Etsuro Orito
Conference paper

Abstract

Chronic hepatitis C is a common disease worldwide and is a major cause of chronic liver disease in many countries. However, the current standard therapy of chronic hepatitis C with interferon (IFN) is rather unsatisfactory [1–3]. Therefore, the search for additional therapies needs to be pursued. Molecular evolutionary analysis has been applied to numerous studies of hepatitis C virus (HCV) and has given many informative suggestions. However, it has not yielded helpful information for developing effective antiviral drugs against chronic HCV infection.

Keywords

Substitution Pattern Mutation Pattern Human Immunodeficiency Virus Replication Full Code Region Nucleotide Substitution Pattern 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1999

Authors and Affiliations

  • Masashi Mizokami
    • 1
  • Tatsunori Nakano
    • 1
  • Etsuro Orito
    • 1
  1. 1.Second Department of MedicineNagoya City University Medical SchoolMizuho-ku, NagoyaJapan

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