Natural Variation in Translational Activities of the 5′ Nontranslated RNAs of Genotypes 1a and 1b Hepatitis C Virus: Evidence for a Long Range RNA-RNA Interaction Outside of the Internal Ribosomal Entry Segment
Hepatitis C virus (HCV) is a positive-stranded, enveloped RNA virus which is classified within the hepacivirus genus of the family Flaviviridae . There is extensive genetic heterogeneity among different HCV strains, with at least six major genotypes and a series of related subtypes recognized thus far [2,3]. Among these, genotype 1 is predominant worldwide and comprised of two major subtypes, genotypes la and lb . Although some clinical studies have found no differences in the clinical expression of liver disease that are related to the genotype of the infecting virus , others have suggested that genotype lb infections may be more resistant to interferon therapy [5,6], and may confer greater risk for development of hepatocellular carcinoma than infection with nongenotype lb strains including genotype la viruses .
KeywordsTranslational Activity Hepatitis Delta Virus Internal Ribosomal Entry Sequence Internal Ribosomal Entry Segment Dicistronic Transcript
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