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Different Quasispecies of Hepatitis C Virus in Human Serum, Peripheral Blood Mononuclear Cells, and Liver

  • Keisuke Hino
  • Michiari Okuda
  • Masaaki Korenaga
  • Yuhki Yamaguchi
  • Yoshiharu Katoh
  • Kiwamu Okita
Conference paper

Abstract

Several lines of evidence suggest that hepatitis C virus (HCV) can infect peripheral blood mononuclear cells (PBMCs) in persistently infected individuals on the basis of specific detection of negative-strand hepatitis C virus (HCV) RNA in PBMCs by reverse transcription-polymerase chain reaction (RT-PCR) and in situ hybridization [1–5]. However, direct information on the pathogenic implication of HCV infection of PBMCs is limited.

Keywords

Peripheral Blood Mononuclear Cell Hypervariable Region Predominant Clone Pathogenic Implication Distinct Amino Acid Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1999

Authors and Affiliations

  • Keisuke Hino
    • 1
  • Michiari Okuda
    • 1
  • Masaaki Korenaga
    • 1
  • Yuhki Yamaguchi
    • 1
  • Yoshiharu Katoh
    • 1
  • Kiwamu Okita
    • 1
  1. 1.First Department of Internal MedicineYamaguchi University, School of MedicineUbe, Yamaguchi 755Japan

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