Different Quasispecies of Hepatitis C Virus in Human Serum, Peripheral Blood Mononuclear Cells, and Liver

  • Keisuke Hino
  • Michiari Okuda
  • Masaaki Korenaga
  • Yuhki Yamaguchi
  • Yoshiharu Katoh
  • Kiwamu Okita
Conference paper


Several lines of evidence suggest that hepatitis C virus (HCV) can infect peripheral blood mononuclear cells (PBMCs) in persistently infected individuals on the basis of specific detection of negative-strand hepatitis C virus (HCV) RNA in PBMCs by reverse transcription-polymerase chain reaction (RT-PCR) and in situ hybridization [1–5]. However, direct information on the pathogenic implication of HCV infection of PBMCs is limited.


Peripheral Blood Mononuclear Cell Hypervariable Region Predominant Clone Pathogenic Implication Distinct Amino Acid Sequence 
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Copyright information

© Springer-Verlag Tokyo 1999

Authors and Affiliations

  • Keisuke Hino
    • 1
  • Michiari Okuda
    • 1
  • Masaaki Korenaga
    • 1
  • Yuhki Yamaguchi
    • 1
  • Yoshiharu Katoh
    • 1
  • Kiwamu Okita
    • 1
  1. 1.First Department of Internal MedicineYamaguchi University, School of MedicineUbe, Yamaguchi 755Japan

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