Abstract
Antidepressant drugs have been used clinically not only for depression but also for other psychiatric disorders. Despite extensive studies, the mechanisms of action of antidepressant drugs have not been clearly established. The classic monoamine hypothesis of depression suggests that depressive disorders are associated with subnormal monoamine release at certain synapses of the CNS. Antidepressant drugs are supposed to increase the availability of noradrenaline and serotonin, either by inhibiting amine reuptake or by blocking monoamine oxidase in presynaptic nerve terminals, and facilitate monoamine transmission (Schildkraut 1965). However, an acute effect of antidepressants on neurotransmission is inconsistent with the delayed onset of clinical efficacy of these drugs (Zemlan and Garver 1990). Furthermore, neuroleptic drugs such as amphetamine and cocaine that block reuptake or catabolism of monoamines do not have an antidepressant effect. Thus, an acute neurochemical effect of antidepressant drugs may not account for the mechanism of action of these drugs.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Amir-Zaltsman Y, Ezra E, Scherson T, Zutra A, Littauer UZ, Salomon Y (1982) ADP- ribosylation of microtubule proteins as catalyzed by cholera toxin. EMBO J 1: 181–186
Bhattacharyya B, Sackett DL, Wolff J (1985) Tubulin, hybrid dimers and tubulin S: stepwise charge reduction and polymerization. J Biol Chem 260: 10208–10216
Chen J, Rasenick MM (1995a) Chronic treatment of C6 glioma cells with antidepres¬sant drugs increases functional coupling between a G protein ( Gs) and adenylyl cyclase. J Neurochem 64: 724–732
Chen J, Rasenick MM (1995b) Chronic antidepressant treatment facilitates G protein activation of adenylyl cyclase without altering G protein content. J Pharmacol Exp Ther 275: 509–517
Cowburn RF, Marcusson JO, Eriksson A, Wiehager B, ONeill C (1994) Adenylyl cyclase and G protein subunit levels in postmortem frontal cortex of suicide victims. Brain Res 633: 297–304
De Montis GM, Devoto P, Gessa GL, Procella A, Serra G, Tagliamonte A (1990) Selective adenylate cyclase increase in the limbic area of long-term imipramine- treated rats. Eur J Pharamcol 180: 169–174
Hagmann J, Fishman PH (1980) Modulation of adenylate cyclase in intact macrophage by microtubules: opposing actions of colchicine and chemotactic factor. J Biol Chem 255: 2659–2662
Hatta S, Ameniya N, Ohshika H, Saito T, Ozawa H (1992) Tubulin modifies neuronal sinal transduction through the association with G-proteins in rat cerebral cortex and striatum. Soc Neurosci Abstr 18: 285
Hatta S, Ozawa H, Saito T, Ohshika H (1994) Alteration of tubulin-Gi protein interac¬tion in rat cerebral cortex with aging. J Neurochem 63: 1104–1110
Hatta S, Ozawa H, Saito T, Ohshika H (1995a) Participation of tubulin in the stimula¬tory regulation of adenylyl cyclase in rat cerebral cortex membranes. J Neurochem 64: 1343–1350
Hatta S, Ozawa H, Saito T, Ameniya N, Ohshika H (1995b) Tubulin stimulates adenylyl cyclase activity in rat striatal membranes via transfer of guanine nucleotide to Gs protein. Brain Res 704: 23–30
Jameson L, Caplow M (1981) Modification of microtubule steady-state dynamics by phosphorylation of the microtubule-associated proteins. Proc Natl Acad Sci USA 78: 3413–3417
Jameson L, Frey T, Zeeberg B, Dalldorf F, Caplow M (1980) Inhibition of microtubule assembly by phosphorylation of microtubule-associated proteins. Biochemistry 19: 2472–2479
Kamada H, Ozawa H, Saito T, Hatta S, Takahata N (1997) Dimeric tubulin-stimulated adenylyl cyclase activity is augmented after long-term amitriptyline treatment. Life Sci 60: 57–66
Kennedy MS, Insel PA (1979) Inhibitors of microtubule assembly enhance beta- adrenergic and prostaglandin Erstimulated cyclic accumulation in S49 lymphoma cells. Mol Pharmacol 16: 215–223
Kim H, Jensen C, Rebhun L (1986) The binding of MAP-2 and tau on brain microtu¬bules in vitro: implications for microtubule structure. Ann NY Acad Sci 466: 218–239
Lim L-K, Sekura RD, Kaslow HR (1985) Adenine nucleotides directly stimulate pertussis toxin. J Biol Chem 260: 2585–2588
Littauer U, Giveon D, Thierauf M, Ginsburg I, Postingl H (1985) Tubulin binding sites for microtubule associated proteins. In: De Brabander M, De Mey J (eds) Microtubules and microtubule inhibitors 1985. Elsevier Science Publishers B.V., Amsterdam, pp 171–176
Maccioni R, Serrono L, Avila J (1985) Structural and functional domains of tubulin. BioEssays 4: 165–169
Menkes DB, Rasenick MM, Wheeler MA, Bitensky NW (1983) Guanosine triphos-phate activation of brain adenylate cyclase: enhancement by long-term antidepres¬sant treatment. Science 219: 65–67
Miyamoto S, Asakura M, Sasuga Y (1995) Effect of chronic administration of antide¬pressants on microtubule assembly in rat cerebral cortex. Jpn J Psychopharmacol 15:385–395 (abstract in English)
Newman ME, Lerer B (1989) Post-mediated increases in adenylate cyclase activity after chronic antidepressant treatment: relationship to receptor desensitization. Eur J Pharmacol 162: 345–352
Ozawa H, Rasenick MM (1989) Coupling of the stimulatory GTP-binding protein Gs to rat synaptic membrane adenylate cyclase is enhanced subsequent to chronic antidepressant treatment. Mol Pharmacol 36: 803–808
Ozawa H, Rasenick MM (1991) Chronic electroconvulsive treatment augments cou¬pling of the GTP-binding protein Gs to the catalytic moiety of adenylyl cyclase in a manner similar to that seen with chronic antidepressant drugs. J Neurochem 56: 330–338
Ozawa H, Katamura Y, Hatta S, Amemiya N, Saito T, Ohshika H, Takahata N (1994) Antidepressants directly influence in situ binding of guanine nucleotide in synaptic membrane. Life Sci 54: 925–932
Perez J, Tinelli D, Brunello N, Racagni G (1989) cAMP-dependent phosphorylation of soluble and crude microtubule fractions of rat cerebral cortex after prolonged desmethylimipramine treatment. Eur J Pharmacol Mol Pharmacol Sec 172: 305–316
Popova JS, Garrison JC, Rhee SG, Rasenick MM (1997) Tubulin, Gq, and phos- phatidylinositol 4,5-bisphosphate interact to regulate phospholipase Cp! signaling. J Biol Chem 272: 6760–6765
Rasenick MM, Wang N (1988) Exchange of guanine nucleotides between tubulin and GTP-binding proteins that regulate adenylate cyclase: cytoskeletal modification of neuronal signal transduction. J Neurchem 51: 300–311
Rasenick MM, Stein P, Bitensky MW (1981) The regulatory subunit of adenylate cyclase interacts with cytoskeletal components. Nature 294: 560–562
Rasenick MM, O’Callahan CM, Moore CA, Kaplan RS (1985) GTP-binding proteins which regulate neuronal adenylate cyclase interact with microtubule proteins. In: De Brabander M, De Mey J (eds) Microtubules and microtubule inhibitors 1985. Elsevier Science Publishers B.V., Amsterdam, pp 313–323
Roychowdhury S, Wang N, Rasenick MM (1994) Tubulin-G protein association stabi¬lizes GTP binding and activates GTPase: cytoskeletal participation in neuronal signal transduction. Biochemistry 33: 9800–9805
Rudolph SA, Hegstrand LR, Greengard P, Malawista SE (1979) The interaction of colchicine with hormone-sensitive adenylate cyclase in human leukocytes. Mol Pharmacol 16: 805–812
Schildkraut JJ (1965) The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry 122: 509–522
Schulman H (1984) Differential phosphorylation of MAP-2 stimulated by calcium-calmodulin and cyclic AMP. Mol Cell Biol 4: 1175–1178
Stephens RE (1986) Membrane tubulin. Biol Cell 57: 95–110
Sulser F (1984) Antidepressant treatments and regulation of norepinephrine- receptor-coupled adenylate cyclase systems in brain. Adv Biochem Psychopharmacol 39: 249–261
Wang N, Rasenick MM (1991) Tubulin-G protein interactions involve microtubule polymerization domains. Biochemistry 30: 10957–10965
Wang N, Yan K, Rasenick MM (1990) Tubulin binds specifically to the signal-transducing proteins, Gsa and GioCj. J Biol Chem 265: 1239–1242.
Yamamoto H, Tomita U, Mikuni M, Kobayasi I, Kagaya A, Katada T, Ui M, Takahashi K (1992) Direct activation of purified Go-type GTP binding protein by tricyclic antidepressants. Neurorosci Lett 139: 194–196
Yan K, Greene E, Belga F, Rasenick MM (1996) Synaptic membrane G proteins are complexed with tubulin in situ. J Neurochem 66: 1489–1495
Zemlan FP, Garver DL (1990) Depression and antidepressant therapy: receptor dy¬namics. Prog Neuropsychopharmacol Biol Psychiatry 14: 503–523
Zisapel N, Levi M, Gozes I (1980) Tubulin: an integral protein of mammalian synaptic vesicle membranes. J Neurochem 34: 26–32
Zor U (1983) Role of cytoskeletal organization in the regulation of adenylate cyclase- cyclic adenosine monophosphate by hormones. Endocr Rev 4: 1–21
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag Tokyo
About this paper
Cite this paper
Hatta, S., Ohshika, H. (1998). Participation of Cytoskeletal Elements in Neuronal Signal Transduction: New Insight into the Molecular Basis of Antidepressant Action. In: Ozawa, H., Saito, T., Takahata, N. (eds) Signal Transduction in Affective Disorders. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68479-4_9
Download citation
DOI: https://doi.org/10.1007/978-4-431-68479-4_9
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68481-7
Online ISBN: 978-4-431-68479-4
eBook Packages: Springer Book Archive