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Effects of Antidepressants on Transmembrane Signaling

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Signal Transduction in Affective Disorders

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Abstract

Antidepressants are widely used for depression and other psychiatric disorders, but their neurochemical mechanism of action is still unclear. The monoamine hypothesis of affective disorders (Schildkraut 1965) proposes that antidepressants exhibit their therapeutic effects by inhibition of monoamine reuptake in presynaptic nerve terminals, which leads to facilitation of monoamine transmission. However, the acute effects of antidepressants on neurotransmission are inconsistent with the delayed onset of their clinical efficacy (Zelman and Garver 1990). Moreover, some monoamine reuptake inhibitors, such as cocaine, do have not an antidepressant effect.

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Authors and Affiliations

  1. Department of Occupational Therapy, School of Health Sciences, Sapporo Medical University, S.3, W.17, Chuo-ku, Sapporo, Hokkaido 060, Japan

    Toshikazu Saito

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  1. Toshikazu Saito
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Editors and Affiliations

  1. Department of Neuropsychiatry, School of Medicine, Sapporo Medical University, S-1, W-16, Chuo-ku, Sapporo, Hokkaido 060, Japan

    Hiroki Ozawa M.D., Ph.D. (Instructor) & Naohiko Takahata M.D., Ph.D. (Professor) (Instructor) &  (Professor)

  2. Department of Occupational Therapy, School of Health Science, Sapporo Medical University, S-1, W-16, Chuo-ku, Sapporo, Hokkaido 060, Japan

    Toshikazu Saito M.D., Ph. D. (Professor) (Professor)

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© 1998 Springer-Verlag Tokyo

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Saito, T. (1998). Effects of Antidepressants on Transmembrane Signaling. In: Ozawa, H., Saito, T., Takahata, N. (eds) Signal Transduction in Affective Disorders. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68479-4_1

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  • DOI: https://doi.org/10.1007/978-4-431-68479-4_1

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68481-7

  • Online ISBN: 978-4-431-68479-4

  • eBook Packages: Springer Book Archive

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