Effects of Antidepressants on Transmembrane Signaling

  • Toshikazu Saito
Conference paper


Antidepressants are widely used for depression and other psychiatric disorders, but their neurochemical mechanism of action is still unclear. The monoamine hypothesis of affective disorders (Schildkraut 1965) proposes that antidepressants exhibit their therapeutic effects by inhibition of monoamine reuptake in presynaptic nerve terminals, which leads to facilitation of monoamine transmission. However, the acute effects of antidepressants on neurotransmission are inconsistent with the delayed onset of their clinical efficacy (Zelman and Garver 1990). Moreover, some monoamine reuptake inhibitors, such as cocaine, do have not an antidepressant effect.


Affective Disorder Adenylyl Cyclase Transmembrane Signaling Guanosine Triphosphate Monoamine Reuptake 
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Copyright information

© Springer-Verlag Tokyo 1998

Authors and Affiliations

  • Toshikazu Saito
    • 1
  1. 1.Department of Occupational Therapy, School of Health SciencesSapporo Medical UniversitySapporo, Hokkaido 060Japan

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