Intracarotid Recombinant Tissue Plasminogen Activator in Acute Carotid Artery Territory Stroke

  • Y. Yoneda
  • E. Mori


Our previous intravenous, double-blind, placebo-controlled trial of recombinant tissue plasminogen activator (rt-PA) [1] and other intravenous rt-PA trials [2–4] indicated that systemic administration of rt-PA was safe and effective in treating acute carotid artery territory embolic stroke. However, the recanalization efficacy demonstrated in those trials [1–4] was limited; recanalization frequency was at most 50%. Local intraarterial infusion is assumed to be safer and more effective than intravenous infusion by reduction of systemic side effects and increase of recanalization. To examine this assumption, we conducted an intraarterial rt-PA trial. We report here an interim analysis of our ongoing intracarotid trial, and the results are compared with those in our intravenous trial [1].


Internal Carotid Artery Acute Ischemic Stroke Tissue Plasminogen Activator Hemorrhagic Transformation Recombinant Tissue Plasminogen Activator 
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Copyright information

© Springer-Verlag Tokyo 1995

Authors and Affiliations

  • Y. Yoneda
    • 1
  • E. Mori
    • 2
  1. 1.Neurology ServiceHyogo Brain and Heart Center at HimejiHimeji, 670Japan
  2. 2.Department of Clinical NeurosciencesHyogo Institute for Aging Brain and Cognitive DisordersHimeji, 670Japan

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