“Central” Intraarterial Thrombolysis Using a Newly Developed Low Friction Guidewire/Catheter System
Fibrinolytic therapy for cerebral embolism was initially accomplished by intravenous administration of urokinase and streptokinase. Although this was technically easy, results were far from satisfactory; no significant change was seen in treated patients compared with the control group, and mortality rate was high among the treated group . Therefore, this method was abandoned. In recent years, clinical trials in treating patients with cerebral embolism by intravenous administration of a new fibrinolytic agent recombinant tissue plasminogen activator (rt-PA), which has a strong affinity to fibrin in the embolus, have been done. This was said to be effective compared to the control group, but the reported recanalization rate, which was 30%–50%, was not yet satisfactory [2,3]. Furthermore, this seems to be more effective for small emboli lodging in the cortical branches than large emboli lodging in the more proximal arteries.
KeywordsCerebral Artery Fibrinolytic Therapy Cerebral Embolism Fibrinolytic Agent Intraarterial Thrombolysis
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