Intracranial Hemorrhage in Association with Thrombolysis: Multiple Causes and Risk Factors (No Simple Answer)

  • M. S. Pessin
  • G. J. del Zoppo
Conference paper


The simple view to account for intracranial hemorrhage (ICH) in acute stroke patients treated with thrombolytic agents has been reperfusion bleeding into an area of infarcted tissue from an occluded, then recanalized, artery weakened by an ischemic insult. However, the emerging data from the acute myocardial infarction (MI) and the acute stroke studies suggest that the origin of ICH may be more complex. The occurrence of symptomatic, even debilitating ICH in the setting of thrombolytic therapy for acute MI and for acute stroke is the major safety concern.


Acute Stroke Acute Ischemic Stroke Intracranial Bleeding Thrombolytic Therapy Tissue Plasminogen Activator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Tokyo 1995

Authors and Affiliations

  • M. S. Pessin
    • 1
  • G. J. del Zoppo
    • 2
  1. 1.New England Medical CenterBostonUSA
  2. 2.Scripps Clinic & Research FoundationLa JollaUSA

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