The Multicenter Acute Stroke Trial (MAST)—Thrombolysis Study: Study Design and Progress Report

  • The MAST Group
Conference paper


Acute ischemic stroke is the third major cause of death in developed countries, and a major cause of disability. Despite a very poor prognosis, no treatment has demonstrated an efficacy in lowering the mortality and disability resulting from stroke events. Thrombolysis has been proven to reduce mortality in myocardial infarction [1–3], and it has been shown able to induce recanalization when administered to acute stroke patients. A recent meta-analysis of small-sized studies suggests that thrombolysis could offer some benefit to stroke patients by reducing the mortality and severe invalidity by 63%; these results need to be confirmed in adequately designed and sized studies [4]. The Multicenter Acute Stroke Trial (MAST) is an ongoing stroke trial comparing streptokinase and placebo. Its rationale has been developed elsewhere [5].


Acute Ischemic Stroke Steering Committee Acute Stroke Patient Data Monitoring Committee Drug Supply 
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Copyright information

© Springer-Verlag Tokyo 1995

Authors and Affiliations

  • The MAST Group

There are no affiliations available

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