The Role of P-Selectin and ICAM-1 During Focal Brain Ischemia/Reperfusion

  • Y. Okada
  • G. J. del Zoppo
Conference paper


Recent studies have indicated that polymorphonuclear (PMN) leukocytes may contribute to the “no-reflow” phenomenon after focal cerebral ischemia and reperfusion by binding to the microvascular endothelium in the ischemic corpus striatum [1,2]. The nature of this interaction has been the subject of intense investigation [3]. Little is known about how the affected micro-vascular endothelia respond during focal cerebral ischemia and reperfusion. To understand the role of PMN leukocytes during reperfusion following middle cerebral artery ischemia, the responses of the endothelial cell adhesion receptors, in particular those related to PMN leukocytes, were examined.


Middle Cerebral Artery Middle Cerebral Artery Occlusion Focal Cerebral Ischemia Postcapillary Venule Microvascular Endothelium 
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Copyright information

© Springer-Verlag Tokyo 1995

Authors and Affiliations

  • Y. Okada
    • 1
    • 2
  • G. J. del Zoppo
    • 1
  1. 1.Department of Molecular and Experimental MedicineThe Scripps Research InstituteLa JollaUSA
  2. 2.Cerebrovascular Disease Clinic and Clinical Research InstituteNational Kyushu Medical CenterChuo-ku, Fukuoka, 810Japan

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