Applications of Diffusion-Weighted Magnetic Resonance Imaging for Stroke Diagnosis and Treatment

  • M. Fisher


The availability of imaging technologies to detect the extent of ischemic strokes and associated perfusion deficits shortly after onset would provide a valuable adjunct to the design and execution of therapeutic trials. While computerized tomographic (CT) scanning and standard magnetic resonance imaging (MRI) of the brain provided major advances in the clinician’s capability to assess stroke patients, neither of these imaging modalities can disclose the location or size of focal ischemic brain insults during the critical first few hours after onset. With CT scans, almost 24 h must elapse before an ischemic stroke can be accurately visualized, while standard T1 and T2 MRI requires approximately 12h for reliable ischemic lesion detection [1,2]. Accumulating evidence suggests that the first 4–6 h after stroke onset is the critical period for successful therapeutic intervention, whether by a thrombolytic or a neuroprotective or a combination approach [3].


Ischemic Stroke Apparent Diffusion Coefficient Magn Reson Image Ischemic Lesion Perfusion Deficit 


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Copyright information

© Springer-Verlag Tokyo 1995

Authors and Affiliations

  • M. Fisher
    • 1
  1. 1.Department of NeurologyThe Medical Center off Central Massachusetts and University of Massachusetts Medical SchoolWorcesterUSA

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