New MR Technologies for Diagnosis of Acute Ischemic Stroke: MR Angiography, Diffusion, and Perfusion Imaging

  • S. Warach


Technological advances in magnetic resonance imaging (MRI) continue at a rapid pace. To those familiar with recent advances in what are broadly termed functional MRI techniques, techniques that measure physiological rather than anatomical aspects of the brain, their routine use in acute stroke diagnosis and clinical trials seems inevitable. I limit my remarks here to aspects of these new techniques that are relevant to thrombolytic therapies and therapeutic trials.


Magnetic Resonance Angiography Acute Ischemic Stroke Thrombolytic Therapy Echo Planar Imaging Ischemic Penumbra 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Edelman RR, Mattle HP, Atkinson DJ, Hill T, Finn JP, Mayman C, Ronthal M, Hoogewoud HM, Kleefield J (1990) Cerebral blood flow: assessment with dynamic contrast-enhanced T2*-weighted MR imaging at 1.5 T. Radiology 176: 211–220PubMedGoogle Scholar
  2. 2.
    Edelman RR, Siewert B, Darby DG, Thangaraj V, Nobre AC, Mesulam MM, Warach S (1994) Qualitative mapping of cerebral blood flow and functional localization with EPISTAR MRI. Radiology 192: 513–520PubMedGoogle Scholar
  3. 3.
    Moseley ME, Cohen Y, Mintorovitch J, et al (1990) Early detection of regional cerebral ischemic injury in cats: evaluation of diffusion and T2-weighted MRI and spectroscopy. Magn Reson Med 14: 330–346PubMedCrossRefGoogle Scholar
  4. 4.
    Warach S, Chien D, Li W, Ronthal M, Edelman RR (1992) Rapid diffusion imaging of acute cerebral infarction. Neurology 42: 1717–1723PubMedGoogle Scholar
  5. 5.
    Warach S, Li W, Ronthal M, Edelman RR (1992) Evaluation of acute cerebral ischemia using dynamic contrast-enhanced MR and MR angiography. Radiology 182: 41–47PubMedGoogle Scholar
  6. 6.
    Warach S, Wielopolski P, Edelman RR (1993) Identification and characterization of the ischemic penumbra of acute human stroke using echo planar diffusion and perfusion imaging. In: Proceedings of the 12th Annual Scientific Meeting of the Society of Magnetic Resonance in Medicine. Society of Magnetic Resonance in Medicine, Berkeley, p 263Google Scholar

Copyright information

© Springer-Verlag Tokyo 1995

Authors and Affiliations

  • S. Warach
    • 1
  1. 1.Departments of Neurology and RadiologyHarvard Medical School and Beth Israel HospitalBostonUSA

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