Results of RAFP Therapy on CT Scan

  • J. Shingai


Many studies on the effectiveness of therapy in glioma cases have been reported thus far [1–7, 9–12], but several problems in the analysis of such results have been apparent. In our attempt to avoid such difficulties, we evaluated the effectiveness of radiation + ACNU + FT-207 + PSK (RAFP) therapy in 72 glioma cases by means of computed tomography (CT). Here, we report our results and discuss the various problems encountered in the treatment of glioma and the evaluation of therapeutic results.


Malignant Glioma Remission Rate Anaplastic Astrocytoma Malignant Brain Tumor Anaplastic Glioma 
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  1. 1.
    Craft DC, Levin VA, Edwards MS, Pischer TL, Wilson CB (1978) Chemotherapy of recurrent medulloblastoma with combined procarbazine, CCNU, and vincristine. J Neurosurg 49: 589–592CrossRefGoogle Scholar
  2. 2.
    Duffner PK, Cohen ME, Thomas PRM, Sinks LF, Freeman AI (1979) Combination chemotherapy in recurrent medulloblastoma. Cancer 43: 41–45PubMedCrossRefGoogle Scholar
  3. 3.
    Gutin PH, Wilson CB, Kumar ARV, Boldrey EB, Levin VA, Powell M, Enot KJ (1975) Phase II study of procarbazine, CCNU, and vincristine combination chemotherapy in the treatment of malignant brain tumors. Cancer 35: 1398–1404PubMedCrossRefGoogle Scholar
  4. 4.
    Hildebland J, Brihaye J, Wagenknecht L, Mitchel J, Kenis Y (1973) Combination chemotherapy with l-(2-chloroethyl-3-chlorohexyl-1-nitrosourea) (CCNU), vincristine and methotrexate in primary and metastatic brain tumors—a preliminary report. Eur J Cancer 9: 627–634Google Scholar
  5. 5.
    Levin VA, Hoffman WF, Pischer TL, Seager ML, Boldrey EB, Wilson CB (1978) BCNU-5-fluorouracil combination therapy for recurrent malignant brain tumors. Cancer Treat Rep 62: 2071–2076PubMedGoogle Scholar
  6. 6.
    Levin VA, Wara WM, Davis RL, Vestmys P, Resser KJ, Yatsko K, Nutik S, Gutin PH, Wilson CB (1985) Phase III comparison of BCNU, and vincristine administered after radiotherapy with hydroxyurea for malignant gliomas. J Neurosurg 63: 218–223PubMedCrossRefGoogle Scholar
  7. 7.
    Matsumoto K, Tabuchi K, Furuta T, Fujiwara T, Nakasome S, Onishi R, Moriya Y, Nishimoto A, Doi A, Asari S, Suga T (1983) Combination chemotherapy of brain tumors with ACNU and 5-FU. Neurol Med Chir (Tokyo) 23: 625–632CrossRefGoogle Scholar
  8. 8.
    Mogami H, Ushio Y, Sano K, Takakura K, Handa H, Yamashita J, Uekik, Tanaka R, Hatanaka H, Nomura K (1986) Criteria for evaluating treatment regimens for patients with brain tumors. Neurol Med Chir (Tokyo) 26: 191–194CrossRefGoogle Scholar
  9. 9.
    Pouillart P, Mathe G, Thy TH, Lheritier J, Poisson M, Huguenin P, Gauthier H (1976) Treatment of malignant gliomas and brain metastases in adults with a combination of adriamycin, VM-26, and CCNU: results of a phase II trial. Cancer 38: 1909–1916PubMedCrossRefGoogle Scholar
  10. 10.
    Seiler RW, Greiner RH, Zimmerman A, Markwalder H (1978) Radiotherapy combined with procarbazine, bleomycin and CCNU in the treatment of high-grade supratentorial astrocytomas. J Neurosurg 48: 861–865PubMedCrossRefGoogle Scholar
  11. 11.
    Tanaka R, Murakami N, Suzuki N, Takeda N, Arai H, Konnok, Tanimura K (1984) Radiotherapy using bleomycin, ACNU, and vincristine for malignant brain tumors; efficacy for tumor regression. Neurol Med Chir (Tokyo) 24: 557–563CrossRefGoogle Scholar
  12. 12.
    Zanger E, de Tribolet N, Wagenknecht L (1978) Combined chemotherapy with VM-26 and BCNU for recurrent malignant gliomas after operation and irradiation. Acta Neurochirur (Wien) 42: 97–101CrossRefGoogle Scholar

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© Springer-Verlag Tokyo 1988

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  • J. Shingai

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