A Study of Intratumoral Oxygen Pressure in Brain Tumors
Even today with the development of various immunochemotherapies, radiation therapy remains the principal treatment for malignant brain tumors [27, 35]. It is well known, however, that prevention of recurrence or complete cure in such cases is often not attainable, even with extensive radiation therapy. One cause for this is said to be the presence of hypoxic cells within the tumor tissue. Following the early (1955) advocacy of the concept of hypoxic cells by Thomlinson and Gray , the cells have been observed experimentally in monolayers [10, 13, 36] and spheroids [6, 23], but in all such cases experimental work has been confined to the in vitro situation, rather than the actual measurement of oxygen pressure (PO2) within tumor tissue. In experimental tumors as well, the transplanted tissue tends to be small and it becomes technically difficult to measure PO2 . Futhermore, there have been no reports of PO2 measurements of tumor tissue in a clinical setting [9, 26].
KeywordsBrain Tumor Hypoxic Tissue Normal Brain Tissue Malignant Brain Tumor Hypoxic Cell
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