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Treatment of Glioma pp 109–116Cite as

The Pharmacokinetics of ACNU in Patients with Malignant Brain Tumor

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Abstract

ACNU[l-(4-amino-2-methylpyrimidine-5-yl)-methyl-3-(2-chloroethyl)-3-nitroso-urea hydrochloride] is a water-solube nitrosourea anticancer agent which has been developed in Japan [1, 16]. It contains nitroso (-NO), alkyl (R-CH2-), and carbamoyl (R-N-CO) ligands in common with lipid-soluble nitrosoureas (NU), such as l-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) [5, 6, 9, 15, 20], 1,3-bis(2-chloroethyl)-l -nitrosourea (BCNU) [2, 14, 19, 22], and l-(2-chloroethyl)-3-(4-methylcyclohexyl)-l-nitrosourea (Me-CCNU) [17, 18, 23] (Table 4.1).

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Authors
  1. T. Mori
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Editors and Affiliations

  1. Division of Neurosurgery, Institute of Brain Diseases, School of Medicine, Tohoku University, Sendai, 980, Japan

    Jiro Suzuki MD

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© 1988 Springer-Verlag Tokyo

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Mori, T. (1988). The Pharmacokinetics of ACNU in Patients with Malignant Brain Tumor. In: Suzuki, J. (eds) Treatment of Glioma. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68453-4_4

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  • DOI: https://doi.org/10.1007/978-4-431-68453-4_4

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68455-8

  • Online ISBN: 978-4-431-68453-4

  • eBook Packages: Springer Book Archive

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