Combined Effects of Radiation, ACNU, and 5-FU on Gliomas: An Experimental Combination Therapy

  • S. Mashiyama
  • S. Sugiyama
  • K. Kuwahara
  • M. Kitahara
  • K. Takahashi
  • T. Sasaki


Although surgical removal of the tumor is essential for the treatment of malignant glioma, radiotherapy and chemotherapy have also played important roles in recent years. Improvements in therapeutic results obtained by means of combined therapies continue to be reported [50, 55, 56, 60, 85, 98, 99, 101], but there is a need for further experimental research. We consequently undertook several basic studies on the effectiveness of radiotherapy, l-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU), and 5-fluorouracil (5-FU) either alone or in various combinations and report these results in the present chapter. The possibilities for clinical application of the biological results are also discussed.


Malignant Glioma Malignant Brain Tumor Hypoxic Cell Survive Fraction Multicellular Spheroid 
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© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • S. Mashiyama
  • S. Sugiyama
  • K. Kuwahara
  • M. Kitahara
  • K. Takahashi
  • T. Sasaki

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