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Combined Effects of Radiation, ACNU, and 5-FU on Gliomas: An Experimental Combination Therapy

  • S. Mashiyama
  • S. Sugiyama
  • K. Kuwahara
  • M. Kitahara
  • K. Takahashi
  • T. Sasaki

Abstract

Although surgical removal of the tumor is essential for the treatment of malignant glioma, radiotherapy and chemotherapy have also played important roles in recent years. Improvements in therapeutic results obtained by means of combined therapies continue to be reported [50, 55, 56, 60, 85, 98, 99, 101], but there is a need for further experimental research. We consequently undertook several basic studies on the effectiveness of radiotherapy, l-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU), and 5-fluorouracil (5-FU) either alone or in various combinations and report these results in the present chapter. The possibilities for clinical application of the biological results are also discussed.

Keywords

Malignant Glioma Malignant Brain Tumor Hypoxic Cell Survive Fraction Multicellular Spheroid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • S. Mashiyama
  • S. Sugiyama
  • K. Kuwahara
  • M. Kitahara
  • K. Takahashi
  • T. Sasaki

There are no affiliations available

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