Skip to main content

Clinical Analysis of Glioma: Medulloblastoma

  • Chapter
Treatment of Glioma
  • 38 Accesses

Abstract

Although progress in the treatment of medulloblastoma has been made in recent years [1–6, 9, 10, 12, 14, 15, 21, 23], it is still one of the types of brain tumor with a poor prognosis. Since 1979, we have used radiation therapy combined with chemotherapy using ACNU, FT-207, and PSK (RAFP) to treat medulloblastomas. In this way, we have obtained a 5-year survival rate of 82.5% [20, 22] (Fig. 13.1). Here, we discuss the prognosis and factors influencing the prognosis among the cases experienced at our clinic thus far.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aoki Y (1986) Radiotherapy of medulloblastoma combined with OK-432 (Picibanil ®)—Utilization of its alleviating action on the radiation-induced myelosuppression. J Jpn Soc Cancer Ther 21:1376–1385 (in Japanese)

    CAS  Google Scholar 

  2. Berry MP, Jenkin RDT, Keen CW, Nair BD, Simpson WJ (1981) Radiation treatment of medulloblastoma, 21-year review. J Neurosurg 55:43–51

    Article  PubMed  CAS  Google Scholar 

  3. Bloom HJG (1979) Recent concepts in the conservative treatment of intracranial tumors in children. Acta Neurochirur 50:103–116

    Article  CAS  Google Scholar 

  4. Bloom HJG (1982) Medulloblastoma in children; increasing survival rates and further prospects. Int J Radiat Oncol Biol Phys 8:2023–2027

    Article  PubMed  CAS  Google Scholar 

  5. Bongarts EB, Bamberg M, Nau HE, Schmitt G, Bayindir C (1979) Optimal therapy in medulloblastoma. Acta Neurochirur 50:117–125

    Article  Google Scholar 

  6. Caputy AJ, McCullough DC, Manz H J, Patterson K, Hammock MK (1987) A review of the factors influencing the prognosis of medulloblastoma. J Neurosurg 66: 80–87

    Article  PubMed  CAS  Google Scholar 

  7. Chang CH, Housepian EM, Herberg C (1969) An operative staging system and a megavoltage radiotherapeutic technique for cerebellar medulloblastomas. Radiology 93:1351–1359

    PubMed  CAS  Google Scholar 

  8. Choux M, Lena G (1982) Medulloblastoma. Neurochirur [suppl] 28:117–212

    Google Scholar 

  9. Edwards MS, Levin VA, Wilson CB (1980) Chemotherapy of pediatric posterior fossa tumors. Child’s Brain 7:252–260

    PubMed  CAS  Google Scholar 

  10. Farwell JR, Dohrmann GJ, Flannery JT (1984) Medulloblastoma in childhood: an epidemiological study. J Neurosurg 61:657–664

    Article  PubMed  CAS  Google Scholar 

  11. Gerosa MA, Stefano E, Olivi A, Carteri A (1981) Multidisciplinary treatment of medulloblastoma: A 5-year experience with the SIOP trial. Child’s Brain 8:107–118

    PubMed  CAS  Google Scholar 

  12. Harisiadis L, Chang CH (1977) Medulloblastoma in children: A correlation between staging and results of treatment. Int J Radiat Oncol Biol Phys 2:833–841

    Article  PubMed  CAS  Google Scholar 

  13. Jereb B, Reid A, Ahuja RK (1982) Patterns of failure in patients with medulloblastoma. Cancer 50:2941–2947

    Article  PubMed  CAS  Google Scholar 

  14. Kopelson G, Linggood RM, Kieinman GM (1982) Medulloblastoma in adults: improved survival with supervoltage radiation therapy. Cancer 49:1334–1337

    Article  PubMed  CAS  Google Scholar 

  15. Kopelson G, Linggood RM, Kieinman GM (1983) Medulloblastoma; the indetification of prognostic subgroups and implications for multimodality management. Cancer 51:312–319

    Article  PubMed  CAS  Google Scholar 

  16. Mazza C, Pasqualin A, Da Pian R (1981) Treatment of medulloblastoma in children. Long-term results following surgery, radiation and chemotherapy. Acta Neurochirur 57:163–175

    Article  CAS  Google Scholar 

  17. Mealey J, Hall PV (1977) Medulloblastoma in children. Survival and treatment. J Neurosurg 46: 56–63

    Article  PubMed  Google Scholar 

  18. Orton CG, Ellis F (1973) A simplification in the use of the NSD concept in practical radiotherapy. Br J Radiol 46: 529–537

    Article  PubMed  CAS  Google Scholar 

  19. Paterson E, Farr RF (1953) Cerebellar medulloblastoma: Treatment by irradiation of whole central nervous system. Acta Radiol 39:323–336

    Article  PubMed  CAS  Google Scholar 

  20. Quinlan RA, Franke WW (1983) Molecular interactions in intermediate-sized filaments revealed by chemical cross-linking. Heteropolymers of vimentin and glial filament protein in cultured human glial cell. Eur J Biochem 132:477–484

    Article  PubMed  CAS  Google Scholar 

  21. Raimondi AJ, Tomita T (1979) Medulloblastoma in childhood: Comparative results of partial and total resection. Child’s Brain 5:310–328

    PubMed  CAS  Google Scholar 

  22. Silverman CL, Simpson JR (1982) Cerebellar medulloblastoma: The importance of posterior fossa dose to survival and patterns of failure. Int J Radiat Oncol Biol Phys 8:1869–1876

    Article  PubMed  CAS  Google Scholar 

  23. The committee of Tohoku brain tumor registry (1985) Tohoku brain tumor registry, vol. 1

    Google Scholar 

  24. Tokars RP, Sutton HG, Greim ML (1979) Cerebellar medulloblastoma. Results of a new method of radiation treatment. Cancer 43:129–139

    Article  PubMed  CAS  Google Scholar 

  25. Tomita T, Mclone DG (1986) Medulloblastoma in childhood; results of radical resection and low-dose neuraxis radiation therapy. J Neurosurg 64:238–242

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Tokyo

About this chapter

Cite this chapter

Takahashi, Y. (1988). Clinical Analysis of Glioma: Medulloblastoma. In: Suzuki, J. (eds) Treatment of Glioma. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68453-4_13

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-68453-4_13

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68455-8

  • Online ISBN: 978-4-431-68453-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics