Abstract
In human, cone visual signals in the retina are processed through dual pathways, one involving ON-center bipolar cells (ON-pathway) and the other through OFF-center bipolar cells (the OFF-pathway), while rod visual signal is processed only through the ON-pathway. Little is known about how patients can see when the ON- and/or OFF-pathway is selectively defective. By comparing the monkey’s electroretinogram (ERG) of a blocked ON- or OFF-pathway using glutamate neurotransmitter analogs, we have detected new clinical entities in human where ON- and/or OFF-pathways are blocked in both rod and cone visual pathways. We hypothesized that the complete type of congenital stationary night blindness (CSNB 1) can be a model disease, having a complete dysfunction of only the ON-pathway, while the incomplete type (CSNB 2) has an incomplete dysfunction of both the ON- and OFF-pathways in both rod and cone visual systems. The gene mutation was detected in nyctalopin in CSNB 1, and in L-type calcium channel αl subunit in CSNB 2.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Tokyo
About this paper
Cite this paper
Miyake, Y., Kondo, M., Nakamura, M., Terasaki, H. (2003). Selective Dysfunction of On- and/or Off-Bipolar Cell in Human Diseases. In: Kaneko, A. (eds) The Neural Basis of Early Vision. Keio University International Symposia for Life Sciences and Medicine, vol 11. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68447-3_9
Download citation
DOI: https://doi.org/10.1007/978-4-431-68447-3_9
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68449-7
Online ISBN: 978-4-431-68447-3
eBook Packages: Springer Book Archive