The Role of Ionic Currents in Shaping Light Responses of Retinal Bipolar Cell

  • Akito Ishihara
  • Yoshimi Kamiyama
  • Shiro Usui
Conference paper
Part of the Keio University International Symposia for Life Sciences and Medicine book series (KEIO, volume 11)


Mbl bipolar cell, which is a subclass of bipolar cells in the goldfish retina, dominantly receives inputs from rods [1], and responds to a spot of light with depolarization (ON-type) [2]. Recently, Mbl bipolar cell has been shown to generate spontaneous calcium transients [3], and is capable of light-evoked calcium spike [4]. The spikes would be generated by ionic currents in their axon terminal (AT) [3, 4]. It is essential to analyze the mechanisms using a modeling simulation in order to understand how the ionic current of the cell plays a role in shaping the light responses. In this study, we analyzed the contribution of ionic mechanisms to light responses of Mbl bipolar cell using a mathematical model based on ionic currents.

Key words

Retina Mbl bipolar cell Mathematical model Light responses 


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Copyright information

© Springer-Verlag Tokyo 2003

Authors and Affiliations

  • Akito Ishihara
    • 1
  • Yoshimi Kamiyama
    • 2
  • Shiro Usui
    • 1
  1. 1.Information and Computer SciencesToyohashi University of TechnologyTenpaku-cho, Toyohashi, AichiJapan
  2. 2.Faculty of Information Science and TechnologyAichi Prefectural UniversityNagakute-cho, AichiJapan

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