Abstract
The center-surround organization of the receptive fields is one of the most important properties of retinal neurons. Cone photoreceptors show concentric receptive field; they are hyperpolarized by spot light and depolarized by annulus light. It is widely accepted that the negative feedback from horizontal cells (HCs) generates the surround response of cones. Although accumulating evidence suggests that γ-aminobutyric acid (GABA) mediates the feedback from HC to cones, there are still a number of reports criticizing the GABA hypothesis of HC-cone feedback. In the goldfish, Verweij et al. [1] have reported that the feedback was detectable in the presence of GABA antagonist, and the surround illumination shifted the activation voltage of the cone calcium current (ICa) to be more negative. In the present study, we reexamined the mechanism of feedback to find an answer to this controversy.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Reference
Verweij J, Kamermans M, Spekreijse H (1996) Horizontal cells feed back to cones by shifting the cone calcium-current activation range. Vision Res 36: 3943–3953
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Tokyo
About this paper
Cite this paper
Hirasawa, H., Kaneko, A. (2003). External Proton Mediates the Feedback from Horizontal Cells to Cones in the Newt Retina. In: Kaneko, A. (eds) The Neural Basis of Early Vision. Keio University International Symposia for Life Sciences and Medicine, vol 11. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68447-3_41
Download citation
DOI: https://doi.org/10.1007/978-4-431-68447-3_41
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68449-7
Online ISBN: 978-4-431-68447-3
eBook Packages: Springer Book Archive