Simulation Analysis of Retinal Horizontal Cells

  • Toshihiro Aoyama
  • Yoshimi Kamiyama
  • Shiro Usui
Conference paper
Part of the Keio University International Symposia for Life Sciences and Medicine book series (KEIO, volume 11)


Retinal horizontal cells (HCs) are second-order neurons, which play a fundamental role in forming center-surround receptive fields. Ionic current is an important element for deciding on electrical membrane characteristics. Ionic channels on HCs have been investigated by applying the patch-clamp method and pharmacology techniques. However, it is difficult to elucidate the function of each ionic current for electrical behaviors of the neurons by only using these techniques. The physiological engineering approach is highly effective for understanding ionic current mechanisms. Mathematical models based on physiological knowledge, such as ionic current mechanisms and intracellular information processing systems, are used to understand complicated electrical behavior in neurons. This paper summarizes the studies on analyzing the membrane properties of HCs.

Key words

Horizontal cells Simulation Mathematical model Ionic current Membrane property 


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Copyright information

© Springer-Verlag Tokyo 2003

Authors and Affiliations

  • Toshihiro Aoyama
    • 1
  • Yoshimi Kamiyama
    • 2
  • Shiro Usui
    • 1
    • 3
  1. 1.Brain Science InstituteRIKENWakoSaitamaJapan
  2. 2.Faculty of Information Science and TechnologyAichi Prefectural UniversityNagakuteAichiJapan
  3. 3.Department of Information and Computer SciencesToyohashi University of TechnologyToyohashiAichiJapan

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