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RPE65-Related Proteins Constitute a Retinoid- and Carotenoid-Metabolizing Protein Family Throughout the Animal and Plant Kingdom

  • Hiroshi Sagara
  • Emiko Suzuki
  • Kazushige Hirosawa
Conference paper
  • 144 Downloads
Part of the Keio University International Symposia for Life Sciences and Medicine book series (KEIO, volume 11)

Abstract

Retinal pigment epithelial (RPE) cells play crucial roles in the maintenance of visual functions. The production and regeneration of 11-cis retinal, which serves as the chromophore of the visual pigment rhodopsin, is one of the most important roles of the RPE cells. To date, several genes that encode the enzymes that may participate in the metabolism of retinoids in RPE cells have been identified [1–3]. However, some of the key enzymes presumed to exist in the RPE cell such as isomerohydrolase have not yet been identified. RPE65 is one of the candidate proteins that may be included in retinoid metabolism in RPE cells.

Key words

RPE65 Retinoid Carotenoid Drosophila DRPE65 

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Copyright information

© Springer-Verlag Tokyo 2003

Authors and Affiliations

  • Hiroshi Sagara
    • 1
  • Emiko Suzuki
    • 1
  • Kazushige Hirosawa
    • 1
  1. 1.Division of Fine Morphology, Department of Basic Medical Sciences, The Institute of Medical ScienceThe University of TokyoMinato-ku, TokyoJapan

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