RPE65-Related Proteins Constitute a Retinoid- and Carotenoid-Metabolizing Protein Family Throughout the Animal and Plant Kingdom
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Retinal pigment epithelial (RPE) cells play crucial roles in the maintenance of visual functions. The production and regeneration of 11-cis retinal, which serves as the chromophore of the visual pigment rhodopsin, is one of the most important roles of the RPE cells. To date, several genes that encode the enzymes that may participate in the metabolism of retinoids in RPE cells have been identified [1–3]. However, some of the key enzymes presumed to exist in the RPE cell such as isomerohydrolase have not yet been identified. RPE65 is one of the candidate proteins that may be included in retinoid metabolism in RPE cells.
Key wordsRPE65 Retinoid Carotenoid Drosophila DRPE65
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