S- and M-Cone Electroretinograms in rd7 Mice with NR2E3 Gene Mutation
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Earlier studies have shown that the alterations of the visual function in rd7 mice result from a deletion in the photoreceptor cell-specific nuclear receptor gene, Nr2e3 . Mutations of this gene have been associated with the enhanced S-cone syndrome (ESCS) in humans . Immunohistological studies also showed that the rd7 retina has an increased number of S-cone cells . The purpose of this study was to examine the physiological properties of the S- and M-cones in rd7 mice electrophysiologically.
Key wordsElectroretinogram rd7 mice S-cone