Actions of Brain-Derived Neurotrophic Factor on Function and Morphology of Visual Cortical Neurons
- 143 Downloads
Brain-derived neurotrophic factor (BDNF) is known to play a role in experiencedependent plasticity of the developing visual cortex. For example, BDNF acutely enhances long-term potentiation and blocks long-term depression in the visual cortex of young rats [1–3]. Such acute actions of BDNF are suggested to be mediated mainly through presynaptic mechanisms. A chronic application of BDNF to the visual cortex of kittens is known to expand ocular dominance columns in the cortex . Recently we have demonstrated that BDNF is transferred from presynaptic axon terminals to postsynaptic neurons in an activity-dependent manner, suggesting the possibility that BDNF also has chronic postsynaptic actions . To test this possibility, we carried out two types of experiments.
Key wordsNeurotrophin Glutamate receptor Visual cortex
- 4.Hata Y, Ohshima M, Ichisaka S, et al. (2000) BDNF expands ocular dominance columns in visual cortex in monocularly deprived and non-deprived kittens, but not in adult cats. J Neurosci 20RC57: 1–5.Google Scholar