Actions of Brain-Derived Neurotrophic Factor on Function and Morphology of Visual Cortical Neurons

  • Tadaharu Tsumoto
  • Naoki Takada
  • Keigo Kohara
Conference paper
Part of the Keio University International Symposia for Life Sciences and Medicine book series (KEIO, volume 11)


Brain-derived neurotrophic factor (BDNF) is known to play a role in experiencedependent plasticity of the developing visual cortex. For example, BDNF acutely enhances long-term potentiation and blocks long-term depression in the visual cortex of young rats [1–3]. Such acute actions of BDNF are suggested to be mediated mainly through presynaptic mechanisms. A chronic application of BDNF to the visual cortex of kittens is known to expand ocular dominance columns in the cortex [4]. Recently we have demonstrated that BDNF is transferred from presynaptic axon terminals to postsynaptic neurons in an activity-dependent manner, suggesting the possibility that BDNF also has chronic postsynaptic actions [5]. To test this possibility, we carried out two types of experiments.

Key words

Neurotrophin Glutamate receptor Visual cortex 


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    Hata Y, Ohshima M, Ichisaka S, et al. (2000) BDNF expands ocular dominance columns in visual cortex in monocularly deprived and non-deprived kittens, but not in adult cats. J Neurosci 20RC57: 1–5.Google Scholar
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Copyright information

© Springer-Verlag Tokyo 2003

Authors and Affiliations

  • Tadaharu Tsumoto
    • 1
  • Naoki Takada
    • 1
  • Keigo Kohara
    • 1
  1. 1.CREST/Japan Science and Technology Corporation, and Division of NeurophysiologyOsaka University Graduate School of MedicineSuitaJapan

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