Spatiotemporal Changes in Gap Junctional Communication During Retinal Development and Regeneration of Adult Newt
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Gap junctions are one of the pathways mediating cell-to-cell communications in many biological systems. They form channels allowing ions and small molecules to pass from one cell to another. The presence of gap junctional communication in the vertebrate central nervous system (CNS) including the retina has been well documented by electrical measurements as well as dye coupling. In adult vertebrate retinas, gap junctions often form electrical synapses that mediate the rapid synaptic transmission. However, it has been also reported that gap junctions are present abundantly between cells that are not electrically excitable in the early developmental retina. Functional role(s) of such gap junctions are largely unknown.