Advertisement

Narrow-Field Amacrine Cells Mediate OFF Signals Between B2 Bipolar and Ganglion Cells in the Mouse Retina

  • Yoshihiko Tsukamoto
Conference paper
  • 146 Downloads
Part of the Keio University International Symposia for Life Sciences and Medicine book series (KEIO, volume 11)

Abstract

A rod-cone mixed input type of OFF bipolar cell (B2) comprises the third rod signal pathway in the mouse retina [1]. The B2 cell receives cone input at basal contacts and also rod input at symmetrical contacts that express ionotropic glutamate receptors [2]. Only one fifth of all rod terminals have direct contacts with B2 cell dendrites, but such rod members gather signals from neighboring rods through rod-rod gap Junctions. This third pathway explains the rod responses that persist in OFF ganglion cells after blockage of the other pathways [3].

Key words

Mouse retina Amacrine cell Microcircuitry 

References

  1. 1.
    Tsukamoto Y, Morigiwa K, Ueda M, et al. (2001) Microcircuits for night vision in mouse retina. J Neurosci 21: 8616–8623PubMedGoogle Scholar
  2. 2.
    Hack I, Peichl L, Brandstätter JH (1999) An alternative pathway for rod signals in the rodent retina: Rod photoreceptors, cone bipolar cells, and the localization of glutamate receptors. Proc Natl Acad Sci USA 96: 14130–14135Google Scholar
  3. 3.
    Soucy E, Nirenberg S, Nathans J, et al. (1998) A novel signaling pathway from rod photoreceptors to ganglion cells in mammalian retina. Neuron 21: 481–493PubMedCrossRefGoogle Scholar
  4. 4.
    Field GD, Rieke F (2002) Mechanisms regulating variability of the single photon responses of mammalian rod photoreceptors. Neuron 35: 733–747PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 2003

Authors and Affiliations

  • Yoshihiko Tsukamoto
    • 1
  1. 1.Department of BiologyHyogo College of MedicineHyogoJapan

Personalised recommendations