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GABAergic Modulation of Ephaptic Feedback in the Outer Retina

  • Maarten Kamermans
  • Iris Fahrenfort
  • Trijntje Sjoerdsma
  • Jan Klooster
Conference paper
Part of the Keio University International Symposia for Life Sciences and Medicine book series (KEIO, volume 11)

Abstract

In goldfish, both cones and horizontal cells (HCs) have ionotropic γ-aminobutyric acid (GABA) receptors [1, 2], and HCs release GABA using a GABA transporter [3, 4]. It has been proposed that HCs feed back to cones via this GABAergic system. However, full-field light stimulation does not lead to a closure of a GABA-gated conductance in the cones. Instead, negative feedback from HCs to cones is mediated via an ephaptic mechanism involving hemichannels [5]. This leaves the role of the GABAergic system, present in the outer retina, unexplained.

Key words

Cones Horizontal cells Feedback GABA 

References

  1. 1.
    Kaneko A, Tachibana M (1986) Effects of gamma-aminobutyric acid on isolated cone photoreceptors of the turtle retina. J Physiol 373: 443–461PubMedGoogle Scholar
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    Verweij J, Kamermans M, Negishi K, et al. (1998) GABA sensitivity of spectrally classified horizontal cells in goldfish retina. Vis Neurosci 15: 77–86PubMedCrossRefGoogle Scholar
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    Yazulla S, Kleinschmidt J (1982) Dopamine blocks carrier-mediated release of GABA from retinal horizontal cells. Brain Res 233: 211–215PubMedCrossRefGoogle Scholar
  4. 4.
    Schwartz EA (1987) Depolarization without calcium can release gamma-aminobutyric acid from a retinal neuron. Science 238: 350–355PubMedCrossRefGoogle Scholar
  5. 5.
    Kamermans M, Fahrenfort I, Schultz K, et al. (2001) Hemichannel-mediated inhibition in the outer retina. Science 292: 1178–1180PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 2003

Authors and Affiliations

  • Maarten Kamermans
    • 1
  • Iris Fahrenfort
    • 1
  • Trijntje Sjoerdsma
    • 1
  • Jan Klooster
    • 1
  1. 1.Research Unit Retinal Signal ProcessingThe Netherlands Ophthalmic Research InstitueAmsterdamThe Netherlands

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