Neural Circuit Contributing to the Formation of the Receptive Surround

  • Akimichi Kaneko
  • Hajime Hirasawa
Conference paper
Part of the Keio University International Symposia for Life Sciences and Medicine book series (KEIO, volume 11)


Formation of the center-surround organization of the receptive field is one of the most important functions of the vertebrate retina, and many studies have been reported on its mechanism. Since the historical finding of [1] in turtle cones, it has been widely accepted that the feedback signal from the horizontal cell (HC) is responsible for the formation of the antagonistic surround response of cone photoreceptors. Accumulating evidence has suggested that the feedback from HC to cones is mediated by y-aminobutyric acid (GABA); HCs are GABAergic, they release GABA upon depolarization, and GABA receptors are concentrated at the cone terminal. On the other hand, there are number of reports criticizing the GABA hypothesis of HC-cone feedback.

Key words

Cone photoreceptor Horizontal cell Receptive field surround 


  1. 1.
    Baylor DA, Fuortes MG, O’Bryan PM (1971) Receptive fields of cones in the retina of the turtle. J Physiol 214: 265–294PubMedGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 2003

Authors and Affiliations

  • Akimichi Kaneko
    • 1
  • Hajime Hirasawa
    • 1
  1. 1.Department of Physiology, School of MedicineKeio UniversityTokyoJapan

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