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Underlying Morphological Changes in the Arterial Wall at Bifurcations for Atherogenesis

  • Y. Yoshida
  • T. Oyama
  • S. Wang
  • T. Yamane
  • M. Mitsumata
  • T. Yamaguchi
  • G. Ooneda

Abstract

Apical and outer wall intimas at branchings of inferior mesenteric arteries from aortas of human autopsy cases were investigated. The outer wall intima, a low shear stress region, was thicker than the apical intima, a high shear stress region, except in cases younger than one month. Deposit of ß-lipoproteins in the outer wall intima increased with age, but not that in the apical intima. Electron microscopic studies revealed that collagen fibers increased markedly in the apical intima in the third decade. Among the dense collagen fibers, intimai smooth muscle cells(SMC) exhibited contractile phenotype. The outer wall possessed mucinous intima accompanied with synthetic SMC. Atherosclerotic rabbit intimai SMC cultivated on type 1 collagen gel increased cAMP production to change phenotype from synthetic to contractile and to suppress DNA synthesis. Early lipid deposition of rabbits placed on an atherogenic diet within three weeks occurred in special linear areas of flow dividers. As a result, blood flow dynamics may induce cellular and microarchitectural changes in vessel walls which are favorable or resistant to atherogenesis.

Keywords

Outer Wall Lipid Deposition Intimal Thickness Atherogenic Diet Flow Divider 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • Y. Yoshida
    • 1
  • T. Oyama
    • 1
  • S. Wang
    • 1
  • T. Yamane
    • 1
  • M. Mitsumata
    • 1
  • T. Yamaguchi
    • 2
  • G. Ooneda
    • 3
  1. 1.Department of PathologyYamanashi Medical CollegeTamahoJapan
  2. 2.Department of Vascular PhysiologyNational Cardiovascular Center Research InstituteSuita, 565Japan
  3. 3.Geriatrics Research Institute and HospitalMaebashi, 371Japan

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