An Hypothesis for the Localization of Atherogenesis and Its Relationship to Endothelial Regulation and Transport

  • S. Weinbaum
  • R. Pfeffer
  • S. Chien
Conference paper


A new hypothesis is advanced for the localization of atherogenesis in which the initial event in the formation of a foam cell lesion is a localized increase in endothelial permeability to LDL due to transient open junctions in regions of elevated cell turnover. The new hypothesis attempts to relate this initial event to a complex sequence of reactions involving a new model for the mediation of LDL receptors on the basal side of the endothelial cell, the subsequent recruitment of monocytes and their conversion to macrophages subject to endothelial mediation and finally the migration and proliferation of smooth muscle cells in the intima.


Artery Wall Cell Turnover Leakage Site Junctional Strand Cholesterol Oleate 
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Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • S. Weinbaum
    • 1
  • R. Pfeffer
    • 2
  • S. Chien
    • 3
  1. 1.Department of Mechanical EngineeringThe City College of the City University of New YorkNew YorkUSA
  2. 2.Department of Chemical EngineeringThe City College of the City University of New YorkNew YorkUSA
  3. 3.Department of PhysiologyColumbia University Medical SchoolNew YorkUSA

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