Advertisement

An Hypothesis for the Localization of Atherogenesis and Its Relationship to Endothelial Regulation and Transport

  • S. Weinbaum
  • R. Pfeffer
  • S. Chien
Conference paper

Abstract

A new hypothesis is advanced for the localization of atherogenesis in which the initial event in the formation of a foam cell lesion is a localized increase in endothelial permeability to LDL due to transient open junctions in regions of elevated cell turnover. The new hypothesis attempts to relate this initial event to a complex sequence of reactions involving a new model for the mediation of LDL receptors on the basal side of the endothelial cell, the subsequent recruitment of monocytes and their conversion to macrophages subject to endothelial mediation and finally the migration and proliferation of smooth muscle cells in the intima.

Keywords

Artery Wall Cell Turnover Leakage Site Junctional Strand Cholesterol Oleate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Brown MS, Goldstein JL (1984) Scientific. Am. 251, 58–66CrossRefGoogle Scholar
  2. 2.
    Miniek CR, Stemerman MB, Insull Jr. W (1977) Proc. Natl. Acad. Sci. 74,1724–1728CrossRefGoogle Scholar
  3. 3.
    Ross R, Glomset JA (1976) N.Engl. J. Med. 295, 369–377PubMedCrossRefGoogle Scholar
  4. 4.
    Ross R (1986) N. Engl. J. Med. 314, 488–500PubMedCrossRefGoogle Scholar
  5. 5.
    Faggiatto A, Ross R, Harker L (1984) Arteriosclerosis. 4. 323–340CrossRefGoogle Scholar
  6. 6.
    Weinbaum S, Tzeghai G, Ganatos P, Pfeffer R, Chien S (1985) Am J. Physiol. 248, H945–H960.PubMedGoogle Scholar
  7. 7.
    Steinberg D (1983) Arteriosclerosis 3, 283–301PubMedCrossRefGoogle Scholar
  8. 8.
    Weinbaum S, Wen GB, Ganatos P, Pfeffer R, Lee M, Chien S (1987) “On Transient Diffusion of Macromolecules Through Leaky Junctions and their Subendoethellal Spread” J. Theor. Biol., in review.Google Scholar
  9. 9.
    Stemerman MB, Morrel EM, Burke KR, Colton CK, Smith KA, Lees RS (1986) Arteriosclerosis, 6, 64–70PubMedCrossRefGoogle Scholar
  10. 10.
    Steinberg D, Pittman RC, Carew TE (1985) Annals New York Acad. Sci., Atherosclerosis, ed. K.T. Lee, 454,195–206Google Scholar
  11. 11.
    Reckless JPD, Weinstein DB, Steinberg D (1978) Biochim. Biophys. Acta, 529, 475–487PubMedGoogle Scholar
  12. 12.
    Henriksen T, Mahoney EM, Steinberg D (1983) Arteriosclerosis 3, 149–159PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • S. Weinbaum
    • 1
  • R. Pfeffer
    • 2
  • S. Chien
    • 3
  1. 1.Department of Mechanical EngineeringThe City College of the City University of New YorkNew YorkUSA
  2. 2.Department of Chemical EngineeringThe City College of the City University of New YorkNew YorkUSA
  3. 3.Department of PhysiologyColumbia University Medical SchoolNew YorkUSA

Personalised recommendations