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Endothelial Injury and Accumulation of Cholesterol Ester Derived from Circulating Lipoproteins

  • T. Takano
  • C. Mineo
  • R. Hashida
  • Y. Yagyu-Mizuno
  • K. Nakagami
  • S. Ohkuma
Conference paper

Abstract

To elucidate the mechanism how lipoproteins transport through the endothelial barrier, an in vitro model of transcellular transport of macromolecules was developed.

In this paper, the involvement of endothelial cells and accumulation of cholesterol ester in arterial wall will be discussed from the following aspects. 1. Transcellular transport of lipoproteins through cultured endothelial monolayer. 2. Junctional transport of fluorescein dextran through cultured endothelial monolayer. 3. Endothelial injury In vitro and platelet aggregation.

These aspects may be helpful for understanding the fluid mechanism of blood flow atherogenesis.

Keywords

Endothelial Injury Intercellular Junction Endothelial Monolayer Endothelial Cell Monolayer cAMP Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Ross R, (1986) New England J Med pp 314–500Google Scholar
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    Simionescu N, (1983) Physiol Rev 63: 1536–1579PubMedGoogle Scholar
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    Hashida R, Anamizu C, Kimura J, Ohkuma S, Yoshida Y, Takano T, (1986) Cell Struct Funct 11: 31–42PubMedCrossRefGoogle Scholar
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    Hashida R, Anamizu C, Yagyu-Mizuno Y, Ohkuma S, Takano T, (1986) Cell Struct Funct 11: 343–349PubMedCrossRefGoogle Scholar
  5. [5]
    Mizuno-Yagyu Y, Hashida R, Mineo C, Ikegami S, Ohkuma S, Takano T, (1987) Biochem Pharmacol in pressGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • T. Takano
    • 1
  • C. Mineo
    • 1
  • R. Hashida
    • 1
  • Y. Yagyu-Mizuno
    • 1
  • K. Nakagami
    • 1
  • S. Ohkuma
    • 1
  1. 1.Department of Microbiology and Molecular Pathology, Faculty of Pharmaceutical SciencesTeikyo UniversitySagamikoJapan

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