Endothelial Injury and Accumulation of Cholesterol Ester Derived from Circulating Lipoproteins
To elucidate the mechanism how lipoproteins transport through the endothelial barrier, an in vitro model of transcellular transport of macromolecules was developed.
In this paper, the involvement of endothelial cells and accumulation of cholesterol ester in arterial wall will be discussed from the following aspects. 1. Transcellular transport of lipoproteins through cultured endothelial monolayer. 2. Junctional transport of fluorescein dextran through cultured endothelial monolayer. 3. Endothelial injury In vitro and platelet aggregation.
These aspects may be helpful for understanding the fluid mechanism of blood flow atherogenesis.
KeywordsEndothelial Injury Intercellular Junction Endothelial Monolayer Endothelial Cell Monolayer cAMP Content
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