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Adaptive Enlargement of Arteries in Response to Increased Flow and Increased Intimal Plaque

  • C. K. Zarins
  • S. Glagov
  • D. P. Giddens
Conference paper

Abstract

We studied adaptive changes in artery diameter in response to increased blood flow and increasing intimai plaque. Experimental increase in blood flow through an arteriovenous fistula resulted in an increase in lumen diameter such that wall shear stress was normalized. Increasing intimai plaque in human coronary arteries resulted in arterial enlargement which acted to counter or prevent lumen stenosis. Such enlargement was effective in preventing left main coronary stenosis in arteries with plaques occupying less than 40% of the internal elastic lamina. In the distal left anterior descending coronary artery, the most diseased arteries overcompensated and had enlargement of the lumen despite the presence of extensive plaques. The development of stenosis, preservation of a normal lumen caliber or lumen enlargement may depend on local differences in response and on the relative rates of plaque deposition and compensatory arterial enlargement.

Keywords

Wall Shear Stress Left Anterior Descend Lumen Diameter Left Main Coronary Artery Lumen Area 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. [1].
    Zarins CK, Giddens DP, Bharadvaj BK, Sottiurai VS, Mabon RF, Glagov S. (1983) Carotid bifurcation atherosclerosis: Quantitative correlation of plaque localization with flow velocity profiles and wall shear stress. Circ Res 53: 502–514.PubMedGoogle Scholar
  2. [2].
    Kamiya A, Togawa T. (1980) Adaptive regulation of wall shear stress to flow change in the canine carotid artery. Am J Physiol 239: H14–H21.PubMedGoogle Scholar
  3. [3].
    Zarins CK, Zatina MA, Giddens DP, Ku DN, Glagov S. (1987) Shear stress regulation of artery lumen diameter in experimental atherogenesis. J Vasc Surg 5: 413–20.PubMedGoogle Scholar
  4. [4].
    Bond MG, Adams MR, Bullock BC. (1981) Complicating factors in evaluating coronary artery atherosclerosis. Artery 9: 21–9.PubMedGoogle Scholar
  5. [5].
    Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. (1987) Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 316: 1371–5.PubMedCrossRefGoogle Scholar
  6. [6].
    Zarins CK, Weisenberg E, Kolettis GJ, Stankunavicius R, Glagov S. Differential enlargement of artery segments in response to enlarging atherosclerotic plaques. Submitted to the J of Vasc Surg.Google Scholar

Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • C. K. Zarins
    • 1
  • S. Glagov
    • 2
  • D. P. Giddens
    • 3
  1. 1.Department of SurgeryUniversity of ChicagoChicagoUSA
  2. 2.Dapartment of PathologyUniversity of ChicagoChicagoUSA
  3. 3.The School of Mechanical EngineeringGeorgia Institute of TechnologyAtlantaUSA

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