Distribution of Wall Shear Stress and Microfilament Bundles in Endothelial Cells in Canine Coronary Artery in vivo
The relation between wall shear stress (SS) in vivo and the microfilament bundles (MF) in endothelial cells (EC) in the left anterior descending coronary artery (LAD) was investigated in 5 mongrel dogs. Peak shear stress was determined from the flow velocity profile at its peak velocity using a multigate 20 MHz pulsed Doppler velocimeter. Peak SS at the outer side in LAD was significantly greater than that at the cardiac side. The amount of MF in EC was evaluated in the excised vessel segments with transmission electron microscopy as the ratio of the area filled with MF to the total area of EC (F/C). F/C at the outer side was significantly greater than that at the cardiac side. These results suggested that SS increases the amount of MF in EC in canine coronary artery in vivo.
KeywordsWall Shear Stress Left Anterior Descend Outer Side High Shear Stress Transmission Electron Microscopic Examination
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