Ultrastructural Changes in the Endothelial Surface of Rat Carotid Artery Induced by Blood Flow Load
In order to investigate the effects of blood flow on endothelial cells, blood flow changes were produced by constructing an arteriovenous shunt between common carotid artery and external jugular vein in rats. They were kept for 1 day, 3 days, 7 days, 2 weeks, 4 weeks and 8 weeks after operation. Endothelial surface was examined by scanning electron microscopy (SEM). Morphological changes, such as protrution of endothelial cells, microvilli-like projection and increase of endothelial cell density were observed in shunted artery at 2 and 4 weeks. Decrease of endothelial cell density was observed at 8 weeks. These results suggest that the wall shear stress induces proliferation of endothelial cells and may regurate arterial adaptive dilatation.
KeywordsWall Shear Stress Common Carotid Artery Blood Flow Rate Final Measurement External Jugular Vein
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