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Ultrastructural Changes in the Endothelial Surface of Rat Carotid Artery Induced by Blood Flow Load

A Scanning Electron Microscopical Study

  • Conference paper
Role of Blood Flow in Atherogenesis

Abstract

In order to investigate the effects of blood flow on endothelial cells, blood flow changes were produced by constructing an arteriovenous shunt between common carotid artery and external jugular vein in rats. They were kept for 1 day, 3 days, 7 days, 2 weeks, 4 weeks and 8 weeks after operation. Endothelial surface was examined by scanning electron microscopy (SEM). Morphological changes, such as protrution of endothelial cells, microvilli-like projection and increase of endothelial cell density were observed in shunted artery at 2 and 4 weeks. Decrease of endothelial cell density was observed at 8 weeks. These results suggest that the wall shear stress induces proliferation of endothelial cells and may regurate arterial adaptive dilatation.

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References

  1. Thoma R (1893) Untersuchungen über die Histogenese und Histo-mechanik des Gefasssystems. Stuttgart, Verlag von Ferdinand Enke

    Google Scholar 

  2. Kamiya A, Togawa T (1980) Am J Pathol 248: 540–549

    Google Scholar 

  3. Guyton JR, Hartly CJ (1985) Am J Pathol 248: 540–549

    Google Scholar 

  4. Giddens DP, Zarins CK, Glagov S, Bharadvaj BK (1983) Flow and Atherogenesis in the Human Carotid Bifurcation. In: Schettler G, Neren RM, Schmid-Schonbein H, Morl H, Diehm C(eds) Fluid Dynamics as a Localizing Factor for Atherosclerosis. Springer-Verlag, Berlin Heiderberg New York Tokyo, pp 38–45

    Chapter  Google Scholar 

  5. Masuda H, Kikuchi Y, Nemoto T, Bukhari A, Togawa T, Kamiya A (1982) Biorheology 19: 197–208

    PubMed  CAS  Google Scholar 

  6. Masuda H, Shozawa T, Hosoda S, Kanda M, Kamiya A (1985) Heart and Vessels 1: 65–69

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Second Department of Pathology, Akita University School of Medicine, Akita, 010, Japan

    K. Tohda, H. Masuda, K. Kawamura & T. Shozawa

Authors
  1. K. Tohda
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  2. H. Masuda
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  3. K. Kawamura
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  4. T. Shozawa
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Editor information

Editors and Affiliations

  1. Department of Pathology, Yamanashi Medical College, Tamaho, 409-38, Japan

    Yoji Yoshida

  2. Department of Vascular Physiology, National Cardiovascular Center Research Institute, Suita, 565, Japan

    Takami Yamaguchi

  3. Physiological Flow Studies Unit, Imperial College, London, SW7 2AZ, England

    Colin G. Caro

  4. Department of Pathology, University of Chicago, Chicago, IL, 60637, USA

    Seymour Glagov

  5. Biomechanics Laboratory and School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332-0405, USA

    Robert M. Nerem

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© 1988 Springer-Verlag Tokyo

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Tohda, K., Masuda, H., Kawamura, K., Shozawa, T. (1988). Ultrastructural Changes in the Endothelial Surface of Rat Carotid Artery Induced by Blood Flow Load. In: Yoshida, Y., Yamaguchi, T., Caro, C.G., Glagov, S., Nerem, R.M. (eds) Role of Blood Flow in Atherogenesis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68399-5_25

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  • DOI: https://doi.org/10.1007/978-4-431-68399-5_25

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68401-5

  • Online ISBN: 978-4-431-68399-5

  • eBook Packages: Springer Book Archive

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