In vivo Responses of Endothelial Cells to Hemodynamic Stress

  • B. L. Langille
  • A. I. Gotlieb
  • D. W. Kim
Conference paper


We have examined endothelial cell integrity and cytoskeleton structure at sites of flow disturbances in the vicinity of mid-abdominal aortic coarctations in rabbits. Coarctations produce high shear stresses in the inflow region and shears that fluctuate rapidly in direction immediately downstream. Both zones are characterized by elevated endothelial cell death and turnover. Furthermore, repair of endothelial injury was inhibited in both areas. Studies of cytoskeleton in the high shear regions demonstrated expression of very large and long actin microfilament bundles (“stress fibres”). We interpret this response as cellular adaptation that may limit shear-related trauma to endothelium.


Stress Fibre High Shear Stress Actin Staining Coarctation Site Abdominal Aortic Coarctation 
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Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • B. L. Langille
    • 1
  • A. I. Gotlieb
    • 1
  • D. W. Kim
    • 1
  1. 1.Vascular Research Laboratory, Department of Pathology, Banting and Best Diabetes CentreUniversity of Toronto, and Toronto General Hospital Research CentreTorontoCanada

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