Cellular Reactions to Blood Flow

  • R. M. Nerem


Recent investigations on mechanisms, through which a hemodynamic role in atherogenesis might be mediated, have focused on the influence of wall shear stress on vascular endothelium. Through cell culture studies, much is now known about endothelial responses to shear stress; however, a number of basic questions remain unanswered. One such question is “how does an endothelial cell recognize and then transduce a fluid mechanic signal?” Also, other cell types are also involved in the development of atherosclerosis, and it is equally important that an understanding of the influence of mechanical stresses on these cell types be achieved.


Shear Stress Smooth Muscle Cell Wall Shear Stress Arterial Wall Mechanical Environment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    Silkworth, JB, Stehbens WE (1975) Angiology 26: 474–487CrossRefGoogle Scholar
  2. [2]
    Nerem RM, Levesque MJ, Cornhill JF (1981) ASME J Biomech Engr 103: 172–177CrossRefGoogle Scholar
  3. [3]
    Levesque MJ, Liepsch D, Moravec S, Nerem RM (1986) Arteriosclerosis 6: 220–229PubMedCrossRefGoogle Scholar
  4. [4]
    Schwartz CJ, Sprague EA, Fowler SR, Kelly JL (1983) Cellular participation in atherogenesis: selected facets of endothelium, smooth muscle, and the peripheral blood monocyte. In: Schettler G, et al. (eds) Proceedings of a Symposium on Fluid Dynamics as a Localizing Factor for Atherosclerosis. Springer Verlag, Berlin Heidelberg, pp. 200–207CrossRefGoogle Scholar
  5. [5]
    Repin VS, Dolgov VV, Zaikina OE, Novikov JD, Antonov AS, Nikoleva MA, Smirnov VN (1984) Atherosclerosis 50: 35–52PubMedCrossRefGoogle Scholar
  6. [6]
    Langille BL, O’Donnell F (1986) Science 231: 405–407PubMedCrossRefGoogle Scholar
  7. [7]
    Dewey CF, Jr., Bussolari SR, Gimbrone MA, Jr., Davies PF (1981) ASME J Biomech Engr 103: 177–185CrossRefGoogle Scholar
  8. [8]
    Eskin SF, Ives CL, McIntire LV, Navaro LT (1984) Microvasc Res 28: 87–94PubMedCrossRefGoogle Scholar
  9. [9]
    Levesque MJ, Nerem RM (1985) ASME J Biomech Engr 107: 341–347CrossRefGoogle Scholar
  10. [10]
    Sato M, Levesque MJ, Nerem RM (1987) Arteriosclerosis 7: 276–286PubMedCrossRefGoogle Scholar
  11. [11]
    de Souza PA, Levesque MJ, Nerem RM (1986) Federation Proc. 45: 471Google Scholar
  12. [12]
    Davies PF, Dewey CF, Jr., Bussolari SR, Gordon EJ, Gimbrone MA, Jr., (1984) J Clin Invest 73: 1121–1129PubMedCrossRefGoogle Scholar
  13. [13]
    Frangos JA, Mclntire LV, Eskin SF (1985) Science 227: 1477–1479PubMedCrossRefGoogle Scholar
  14. [14]
    Grabowski EF, Jaffe EA, Weksler BB (1985) J Lab Clin Med 105: 36–43PubMedGoogle Scholar
  15. [15]
    Sprague EA, Steinbach BL, Nerem RM, Schwartz CJ (1987) Circulation (in press)Google Scholar
  16. [16]
    Gerrity RG, Gross JA, Soby L (1985) Arteriosclerosis 5: 55–56PubMedCrossRefGoogle Scholar
  17. [17]
    Turitto VT, Weiss HJ (1979) Rheology 23: 735CrossRefGoogle Scholar
  18. [18]
    Sakariassen KS, Aarts PAMM, de Groot PG, Houdijk WPM, Sixma JJ (1983) J Lab Clin Med 102: 522–535PubMedGoogle Scholar
  19. [19]
    Rhee B-G, Mclntire LV (1986) Chem Eng Commun 47: 147–161CrossRefGoogle Scholar
  20. [20]
    Leung DYM, Glagov S, Mathews MB (1976) Science 191: 475–477PubMedCrossRefGoogle Scholar
  21. [21]
    Leung DYM, Glagov S. Mathews MB (1977) Experimental Cell Research 109: 285–298PubMedCrossRefGoogle Scholar
  22. [22]
    Davies PF, Remuzzi A, Gordon EJ, Dewey CF, Jr., Gimbrone MA, Jr. (1986) Proc Natl Acad Sci 83: 2114–2117..PubMedCrossRefGoogle Scholar
  23. [23]
    Levesque MJ, Nerem RM (1983) Shear and pressure effects on cultured endothelial cells In: Proc. 36th Annual Conference on Engineering in Medicine and Biology, held September 11–14, 1983, Columbus, Ohio, p. 34.1Google Scholar
  24. [24]
    Thubriker MJ, Manuel L, Eppink RL (1987) Intramural stress at arterial bifurcation in vivo. In: Proc 40th Annual Conference on Engineering in Medicine and Biology, held September 10–13, 1987, Niagara Falls, NY p. 34.1Google Scholar

Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • R. M. Nerem
    • 1
  1. 1.Biomechanics LaboratoryBioengineering Center, Georgia Institute of TechnologyAtlantaUSA

Personalised recommendations