Cellular Reactions to Blood Flow
Recent investigations on mechanisms, through which a hemodynamic role in atherogenesis might be mediated, have focused on the influence of wall shear stress on vascular endothelium. Through cell culture studies, much is now known about endothelial responses to shear stress; however, a number of basic questions remain unanswered. One such question is “how does an endothelial cell recognize and then transduce a fluid mechanic signal?” Also, other cell types are also involved in the development of atherosclerosis, and it is equally important that an understanding of the influence of mechanical stresses on these cell types be achieved.
KeywordsShear Stress Smooth Muscle Cell Wall Shear Stress Arterial Wall Mechanical Environment
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