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Early Atherosclerosis and Pulsatile Flow in the Human Carotid Bifurcation

  • D. N. Ku
  • C. K. Zarins
  • D. P. Giddens
  • S. Glagov

Abstract

Three regions in the human arterial system are predisposed to the development of intimai thickening, including the formation of atherosclerotic plaques, which may lead to reductions in blood flow, causing clinical symptoms. These three regions include the coronary arteries, the infrarenal abdominal aorta and arteries to the lower limbs, and the carotid bifurcation. Together these three sites cause most of the clinical problems associated with atherosclerosis. Because these lesions localize in such a predictable manner and are usually well-defined in their axial extent, hemodynamic factors may play an important role in the preferential localization of atherosclerosis.

Keywords

Shear Stress Wall Shear Stress Pulsatile Flow Carotid Bifurcation Carotid Sinus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • D. N. Ku
    • 1
  • C. K. Zarins
    • 2
  • D. P. Giddens
    • 1
  • S. Glagov
    • 3
  1. 1.George W. Woodruff School of Mechanical EngineeringGeorgia Institute of TechnologyAtlantaUSA
  2. 2.Department of SurgeryUniversity of ChicagoChicagoUSA
  3. 3.Department of PathologyUniversity of ChicagoChicagoUSA

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