Flow Patterns and Preferred Sites of Atherosclerosis in Human Coronary and Cerebral Arteries

  • T. Karino
  • T. Asakura
  • S. Mabuchi
Conference paper


Using transparent segments of arteries prepared from humans postmortem, flow patterns and the exact anatomical locations of atherosclerosis in major arteries of the human coronary and intracranial cerebral circulations were studied in detail by means of flow visualization and cinemicrographic techniques. It was found that in both coronary and cerebral arteries, atherosclerotic plaques and wall thickenings were localized exclusively on the outer wall (hip) of one or both daughter vessels at major bifurcations and T-junctions, and at the inner wall of curved segments where flow was either slow or disturbed and formation of secondary and recirculation flows were dominant.


Wall Shear Stress Left Anterior Descend Secondary Flow Recirculation Zone Pulsatile Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    Karino T, Motomiya M (1983) Biorheology 20: 119–127PubMedGoogle Scholar
  2. [2]
    Roach MR (1977) The effects of bifurcations and stenoses on arterial disease. In: Hwang NHC, Norman NA (eds) Cardiovascular Flow Dynamics and Measurements. University Park Press, Baltimore, pp 489–539Google Scholar
  3. [3]
    Roach MR, Cornhill JF, Fletcher J (1978) Atherosclerosis 29: 259–264PubMedCrossRefGoogle Scholar
  4. [4]
    Roach MR, Fletcher J (1979) Atherosclerosis 32: 1–10PubMedCrossRefGoogle Scholar
  5. [5]
    Karino T, Kwong HHM, Goldsmith HL (1979) Biorheology 16: 231–248PubMedGoogle Scholar
  6. [6]
    Karino T, Goldsmith HL (1985) Biorheology 22: 87–104PubMedGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • T. Karino
    • 1
  • T. Asakura
    • 1
  • S. Mabuchi
    • 1
  1. 1.McGill University Medical ClinicMontreal General HospitalMontrealCanada

Personalised recommendations