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Hearing Preservation on Gentamicin Treatment for Meniere’s Disease

  • Hisayoshi Ishizaki
  • Ilmari Pyykkö

Abstract

Meniere’s disease is characterized by episodic vertigo, fluctuating hearing loss, ear fullness and tinnitus. It may be due to increased pressure in one of the inner ear fluid compartments. Fluid in the inner ear chambers are constantly being produced and absorbed by the circulatory system. Any disturbance in this delicate relationship results in over-production or under-absorption of the fluids. This leads to increased fluid pressure (hydrops) that in turn produces dizziness which is often associated with fluctuating hearing loss and tinnitus. Endolymphatic hydrops is generally accepted as the histopathological finding for Meniere’s disease. However, pathophysiology of Meniere’s disease is still controversial.

Keywords

Hearing Loss Hair Cell Outer Hair Cell Hearing Level Hearing Preservation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Schuknecht HF (1957) Ablation therapy in the management of Meniere’s disease. Acta Otolaryngol (Stockh) 132: 3–42Google Scholar
  2. 2.
    Kaasinen S, Pyykkó I, Ishizaki H, Aalto H (1998) Intratympanic gentamicin in Meniere’s disease. Acta Otolaryngol (Stockh) 118: 294–298CrossRefGoogle Scholar
  3. 3.
    Driscoll CLW, Kasperbauer JL, Facer GW, Harner SG, Beatty CW (1997) Low-dose intratympanic gentamicin and the treatment of Meniere’s disease: preliminary results. Laryngoscope 107: 83–89PubMedCrossRefGoogle Scholar
  4. 4.
    Ödkvist LM, Berbenius J, Lundgen A (1984) Topical gentamicin treatment for disabling Meniere’s disease. Acta Otolaryngol Suppl (Stockh) 412: 74–76Google Scholar
  5. 5.
    Kaasinen S, Pyykkö I, Ishizaki H, Aalto H (1995) Effect of intratympanically administered gentamicin on hearing and tinnitus in Meniere’s disease. Acta Otolaryngol (Stockh) Suppl 520: 184–185CrossRefGoogle Scholar
  6. 6.
    Magnusson M, Padoan S (1991) Delayed onset of ototoxic effects of gentamicin in treatment of Meniere’s disease. Acta Otolaryngol (Stockh) 111: 671–676CrossRefGoogle Scholar
  7. 7.
    Aran JM (1995) Current perspective on inner ear toxicity. Otolaryngol Head Neck Surg 112: 133–144PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 2004

Authors and Affiliations

  • Hisayoshi Ishizaki
    • 1
  • Ilmari Pyykkö
    • 2
  1. 1.Dept. of OtolaryngologyKikugawa General HospitalShizuokaJapan
  2. 2.Dept. of OtolaryngologyUniversity of TampereTampereFinland

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