Genes and Hearing: The Molecular Basis of Hearing and Deafness

  • Kunihiro Fukushima
  • Kazunori Nishizaki


Genetic hearing impairment is one of the most frequent causes of deafness from birth. Approximately 1 in 1000 babies has prelingual hearing impairment and about half of these cases have a genetic cause. Thus, genetic hearing impairment is one of the most frequent neurological deficits that is present at birth. Although the total frequency of heterozygotes for the deafness gene in the hearing population is still uncertain, at least 2% of the people have one allele with a GJB2 mutation, known to be presently the most common cause of prelingual deafness.


Hearing Loss Hair Cell Outer Hair Cell Tectrial Membrane Endolymphatic Hydrops 
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Copyright information

© Springer-Verlag Tokyo 2004

Authors and Affiliations

  • Kunihiro Fukushima
    • 1
  • Kazunori Nishizaki
    • 1
  1. 1.Department of Otolaryngology-Head & Neck SurgeryOkayama University Postgraduate School of Medicine and DentistryOkayamaJapan

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