Advertisement

Some Relationships between Echocardiography, Quantitative Ultrasonic Imaging, and Myocardial Tissue Characterization

  • J. G. Miller
Conference paper

Abstract

The goal of this work in tissue characterization is assessment of the heart based on analysis of sound return from the tissue, rather than on dimensions or motion. A number of approaches to the goal of tissue characterization have been proposed including qualitative texture analysis (such as “a sparkling appearance”), quantitative texture analysis (such as run-length statistics), and quantitative parameter-based imaging (such as imaging based on backscatter, attenuation, or velocity.) These approaches have been reviewed in detail in several articles [1–3]. In those reviews and in other reviews [4, 5] contributions from a number of Laboratories to the parameter-based imaging approach have also been summarized. Several additional recent references are provided here [6–13]. In this Chapter we will focus only on the work from our Laboratory in order to provide a coherent and systematic presentation of one approach to the goal of tissue characterization. The original manuscripts referenced provide acknowledgment of the creative contributions of many co-authors from our Laboratory, including especially Julio E. Perez, M.D. and Samuel A. Wickline, M.D. who have been essential collaborators in all of this work. Specifically, we will focus on an approach based primarily on real-time integrated backscatter imaging.

Keywords

Receiver Operating Characteristic Curve Cyclic Variation Tissue Characterization Ultrasonic Beam Parasternal Short Axis View 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    David J. Skorton, James G. Miller, Samuel Wickline, Benico Barzilai, Steve M. Collins, and Julio E. Perez, (1991), Ultrasonic Characterization of Cardiovascular Tissue, in Cardiac Imaging: A Companion to Braunwald’s Heart Disease, ed. Melvin L. Marcus, Heinrich R. Schelbert, David J. Skorton, Gerald L. Wolf, and Eugene Braunwald, 538–556, Chapter 26, W. B. Saunders Company, PhiladelphiaGoogle Scholar
  2. 2.
    Samuel A. Wickline, Julio E. Perez, and James G. Miller, Cardiovascular Tissue Characterization In Vivo, (1993), in Ultrasonic Scattering In Biological Tissue — Chapter 10, ed. Shung KK and Thieme GA, 313–345, CRC Press, Boca Raton FLGoogle Scholar
  3. 3.
    J. E. Perez, S. M. Collins, J. G. Miller, and D. J. Skorton, Ultrasonic Myocardial Tissue Characterization (1990), in Comparative Cardiac Imaging: Function, Flow, Anatomy, Quantitation, ed. Bruce Brundage, 403–414, Aspen Publishing Company, GaithersburgGoogle Scholar
  4. 4.
    J.G. Miller, J.E. Perez, and B.E. Sobel, (1985), Ultrasonic Characterization of Myocardium, Prog Cardiovasc Dis, XXV11I, 85–110Google Scholar
  5. 5.
    Julio E. Perez, James G. Miller, Samuel A. Wickline, Mark R. Milunski, Benico Barzilai, and Burton E. Sobel, (1990), Myocardial Tissue Characterization, in Progress in Cardiology 3/1, ed. Douglas P. Zipes and Derek J. Rowlands, 83–96, Lea & Febiger, PhiladelphiaGoogle Scholar
  6. 6.
    J. Naito, T. Masuyama, J. Tanouchi, T. Mano, H. Kondo, K. Yamamoto, R. Nagano, M. Hori, M. Inoue, T. Kamada, (1994), “Analysis of Transmural Trend of Myocardial Integrated Ultrasound Backscatter for Differentiation of Hypertrophic Cardiomyopathy and Ventricular Hypertrophy Due to Hypertension”, J Am Coll Cardiol, 24, 517–524PubMedCrossRefGoogle Scholar
  7. 7.
    CM Moran, GR Sutherland, T Anderson, RA Riemersma, WN McDicken, (1994), “A Comparison of Methods Used to Calculate Ultrasonic Myocardial Backscatter in the Time Domain”, Ultrasound Med Biol., 20, 543–550PubMedCrossRefGoogle Scholar
  8. 8.
    JRTC Roelantd, GR Sutherland, S Iliceto, D. Linker (Eds), Churchill Livingstone, (1992), “Tissue Characterization in Myocardial Disease” In: Cardiac Ultrasound, 419Google Scholar
  9. 9.
    F. Lattanzi, P. Bellotti, E. Picano, F. Chiarella, A. Mazzarisi, C. Melevendi, G. Forni, L. Landini, A. Distante, C. Vecchio, (1993), “Quantitative Ultrasonic Analysis of Myocardium in Patients with Thalassemia Major and Iron Overload”, Circ, 87, 748–754CrossRefGoogle Scholar
  10. 10.
    L. Landini, A. Pezzano, A. Distante, (1993), “Increased Echodensity of Transiently Asynergic Myocardium in Humans: a Novel Echocardiographic Sign of Myocardial Ischemia”, J Am Coll Cardiol, 21, 199–207PubMedCrossRefGoogle Scholar
  11. 11.
    H.U. Stempfle, C.E. Angermann, P. Kraml, A. Schutz, B.M. Kemkes, K. Theisen, (1993), “Serial Changes During Acute Cardiac Allograft Rejection: Quantitative Ultrasound Tissue Analysis Versus Myocardial Histologic Findings”, J Am Coll Cardiol, 22, 310–317PubMedCrossRefGoogle Scholar
  12. 12.
    D. Lythall, J. Bishop, R.A. Greenbaum, C.I.D. Islely, A.G. Mitchell, D.G. Gibson, M. Yacoub, (1993), “Relationship Between Myocardial Collagen on Echo Amplitude in Non Fibrotic Hearts”, Eur Heart J, 14, 344–350PubMedCrossRefGoogle Scholar
  13. 13.
    G. Gigli, F. Lattanzi, A.R. Lucarini, E. Picano, A. Genovesi-Ebert, C. Marabotti, R. Zunino, A. Mazzarisi, L. Landini, M. Iannetti, (1993), “Normal Ultrasonic Myocardial Reflectivity in Hypertensives: A Tissue Characterization Study”, Hypertension, 21, 329–334PubMedCrossRefGoogle Scholar
  14. 14.
    Lewis J. Thomas III, S.A. Wickline, J.E. Perez, B.E. Sobel, and J.G. Miller, (1986), A Real-Time Integrated Backscatter Measurement System for Quantitative Cardiac Tissue Characterization, IEEE Trans Ultrason Ferroelec Freq Contr, UFFC-33, 27–32Google Scholar
  15. 15.
    Lewis J. Thomas III, Benico Barzilai, Julio E. Perez, Burton E. Sobel, Samuel A. Wickline, and James G. Miller, (1989), Quantitative Real-Time Imaging of Myocardium Based on Ultrasonic Integrated Backscatter, IEEE Trans Ultrason Ferroelec Freq Contr, UFFC-36, 466–470Google Scholar
  16. 16.
    Julio E. Perez, James G. Miller, Samuel A. Wickline, and Mark R. Holland, (1992), Quantitative Ultrasonic Imaging: Tissue Characterization and Instantaneous Quantification of Cardiac Function, Am J Cardiol, 69, 104–111CrossRefGoogle Scholar
  17. 17.
    Eric I. Madaras, Benico Barzilai, J.E. Perez, B.E. Sobel, and J.G. Miller, (1983), Changes in Myocardial Backscatter Throughout the Cardiac Cycle, Ultrasonic Imaging, 5, 229–239PubMedGoogle Scholar
  18. 18.
    Benico Barzilai, Eric I. Madaras, B. E. Sobel, J. G. Miller, and J. E. Perez, (1984), Effects of Myocardial Contraction on Ultrasonic Backscatter Before and After Ischemia, Am. J. Physiol. Soc. (Heart Circ. Physiol. 16), 247, 478–483Google Scholar
  19. 19.
    G.A. Mohr, Zvi Vered, Benico Barzilai, Julio E. Perez, Burton E. Sobel, and J.G. Miller, (1989), Automated Determination of the Magnitude and Time Delay (“Phase”) of the Cardiac Cycle Dependent Variation of Myocardial Ultrasonic Integrated Backscatter, Ultrasonic Imaging, 11, 245–259PubMedGoogle Scholar
  20. 20.
    James F. Loomis Jr., Alan D. Waggoner, Kenneth B. Schechtman, James G. Miller, Burton E. Sobel, and Julio E. Perez, (1990), Ultrasonic Integrated Backscatter 2-D Imaging: Evaluation of M-Mode Guided Acquisition and Immediate Analysis in 55 Consecutive Patients, J Am Soc of Echocardiography, 3, 255–265Google Scholar
  21. 21.
    J.W. Mimbs, D. Bauwens, R.D. Cohen, M. O’Donnell, J.G. Miller, and B.E. Sobel, (1981), Effects of Myocardial Ischemia on Quantitative Ultrasonic Backscatter and Identification of Responsible Determinants, Circ, 49, 89–96CrossRefGoogle Scholar
  22. 22.
    Benico Barzilai, Lewis J. Thomas III, Robert M. Glueck, Jeffrey E. Saffitz, Zvi Vered, Burton E. Sobel, James G. Miller, and Julio E. Perez, (1988), Detection of Remote Myocardial Infarction With Quantitative Real-Time Ultrasonic Characterization, J Am Soc of Echocardiography, 1, 179–186Google Scholar
  23. 23.
    M. O’Donnell, J.W. Mimbs, and J.G. Miller, (1981), The Relationship Between Collagen and Ultrasonic Backscatter in Myocardial Tissue, J Acoust Soc Am, 69, 580–588PubMedCrossRefGoogle Scholar
  24. 24.
    Joel Mobley, Micha S. Feinberg, Hije M. Gussak, Christina E. Banta, Julio E. Perez, James G. Miller, (1994), “On-Line Implementation of Algorithm for Determination of Magnitude and Time Delay of cyclic Variation of Integrated Backscatter in an Echocardiographic Imager”, Ultrasonic Imag-ing,In Press, (Abstract)Google Scholar
  25. 25.
    Zvi Vered, G.A. Mohr, Benico Barzilai, Carl J. Gessler Jr., Samuel A. Wickline, Keith A. Wear, Thomas A. Shoup, Alan N. Weiss, Burton E. Sobel, James G. Miller, and Julio E. Perez, (1989), Ultrasound Integrated Backscatter Tissue Characterization of Remote Myocardial Infarction in Human Subjects, J Am Coll Cardiol, 13, 84–91PubMedCrossRefGoogle Scholar
  26. 26.
    Samuel A. Wickline, Lewis J. Thomas III, J.G. Miller, B.E. Sobel, and J.E. Perez, (1986), Sensitive Detection of the Effects of Reperfusion on Myocardium by Ultrasonic Tissue Characterization With Integrated Backscatter, Circ, 74, 389–400CrossRefGoogle Scholar
  27. 27.
    M. R. Milunski, G. A. Mohr, K. A. Wear, B. E. Sobel, J. G. Miller, and S. A. Wickline, (1989), Early Identification With Ultrasonic Integrated Backscatter of Viable But Stunned Moocardium in Dogs, J Am Coll Cardiol, 14, 462–471PubMedCrossRefGoogle Scholar
  28. 28.
    Mark R. Milunski, Gregory A. Mohr, Julio E. Perez, Zvi Vered, Keith A. Wear, Carl J. Gessler, Burton E. Sobel, James G. Miller, and Samuel A. Wickline, (1989), Ultrasonic Tissue Characterization With Integrated Backscatter: Acute Myocardial Ischemia, Reperfusion, and Stunned Myocardium in Patients, Circ, 80, 491–503CrossRefGoogle Scholar
  29. 29.
    Keith A. Wear, Mark R. Milunski, Samuel A. Wickline, Julio E. Perez, Burton E. Sobel, and James G. Miller, (1989), Differentiation Between Acutely Ischemic Myocardium and Zones of Completed Infarction in Dogs on the Basis of Frequency Dependent Backscatter, J Acoust Soc Am, 85, 2634–2641PubMedCrossRefGoogle Scholar
  30. 30.
    C.E. Metz, (1978), “Basic Principles of ROC Analysis”, Seminars in Nuclear Medicine, VIII, 283–298CrossRefGoogle Scholar
  31. 31.
    Julio E. Perez, Janet B. McGill, Julio V. Santiago, Kenneth B. Schecht-man, Alan D. Waggoner, James G. Miller, and Burton E. Sobel, (1992), Abnormal Myocardial Acoustic Properties in Diabetic Patients and Their Correlation with the Severity of Disease, J Am Coll Cardiol, 19, 1154–1156PubMedCrossRefGoogle Scholar
  32. 32.
    D.J. Skorton, B. Vandenberg, (1992), “Ultrasound Tissue Characterization of the Diabetic Heart: Laboratory Curiosity or Clinical Tool?”, J Am Coll Cardiol, 19, 1163–1164PubMedCrossRefGoogle Scholar
  33. 33.
    T.J. Regan, A.B. Weiss, (1992), “Diabetic Cardiomyopathy”, J Am Coll Cardiol, 19, 1165–1166PubMedCrossRefGoogle Scholar
  34. 34.
    R. F. Wagner, K.A. Wear, J.E. Perez, J.B. McGill, K.B. Schechtman, and J.G. Miller, (1993), Multivariate Tissue Characterization: Unbiased Estimates of Asymptotic Performance Using a Finite Sample. Applications to Cardiac Ultrasonic Tissue Characterization of Diabetics and Normal Controls, Ultrasonic Imaging, 15, 156, (Abstract)Google Scholar
  35. 35.
    Julio E. Perez, Alan D. Waggoner, Benico Barzilai, H. E. Melton, James G. Miller, and Burton E. Sobel, (1992), On-Line Assessment of Ventricular Function by Automatic Boundary Detection and Ultrasonic Backscatter Imaging, J Am Coll Cardiol, 19, 313–320PubMedCrossRefGoogle Scholar
  36. 36.
    Julio E. Perez, Steve C. Klein, David M. Prater, Carolyn E. Fraser, Hiram Cardona, Alan D. Waggoner, Mark R. Holland, James G. Miller, and Burton E. Sobel, (1992), Automated, On-Line Quantification of Left Ventricular Dimensions and Function By Echocardiography with Backscatter Imaging and Lateral Gain Compensation, Am J Cardiol, 70, 1200–1205PubMedCrossRefGoogle Scholar
  37. 37.
    Julio E. Perez, Alan D. Waggoner, Victor G. Davila-Roman, Hiram Cardona, and James G. Miller, (1992), On-Line Quantification of Ventricular Function During Dobutamine Stress Echocardiography, European Heart Journal, 13, 1669–1676PubMedGoogle Scholar
  38. 38.
    Alan D. Waggoner, Benico Barzilai, James G. Miller, and Julio E. Perez, (1993), On-Line Assessment of Left Atrial Area and Function by Echocardiography Automatic Boundary Detection, Circ, 88, 1142–1149CrossRefGoogle Scholar
  39. 39.
    G. H. Brandenburger, J. R. Klepper, J. G. Miller, and D. L. Snyder, (1981), Effects of Anisotropy in the Ultrasonic Attenuation of Tissue on Computed Tomography, Ultrasonic Imaging, 3, 113–143PubMedGoogle Scholar
  40. 40.
    J.R. Klepper, G.H. Brandenburger, J.W. Mimbs, B.E. Sobel, and J.G. Miller, (1981), Application of Phase Insensitive Detection and Frequency Dependent Measurements to Computed Ultrasonic Attenuation Tomography, IEEE Trans Biomed Eng, BME-28, 186–201Google Scholar
  41. 41.
    Jack G. Mottley and J.G. Miller, (1988), Anisotropy of the Ultrasonic Backscatter of Myocardial Tissue: I. Theory and Measurements In Vitro, J Acoust Soc Am, 83, 755–761PubMedCrossRefGoogle Scholar
  42. 42.
    E.I. Madaras, J. Perez, B.E. Sobel, J.G. Mottley, and J.G. Miller, (1988), Anisotropy of the Ultrasonic Backscatter of Myocardial Tissue: II. Measurements In Vivo, J Acoust Soc Am, 83, 762–769PubMedCrossRefGoogle Scholar
  43. 43.
    E.I. Madaras, J. Perez, B.E. Sobel, J.G. Mottley, and J.G. Miller, (1990), Anisotropy of the Ultrasonic Attenuation in Soft Tissues: Measurements In Vitro, Jack G. Mottley and James G. Miller, J Acoust Soc Am, 88, 1203–1210CrossRefGoogle Scholar
  44. 44.
    Alan D. Waggoner, Julio E. Perez, James G. Miller, and Burton E. Sobel, (1992), Differentiation of Normal and Ischemic Right Ventricular Myocardium With Quantitative Two Dimensional Integrated Backscatter Imaging, Ultrasound Med Biol, 18, 249–253PubMedCrossRefGoogle Scholar
  45. 45.
    Dino Recchia, James G. Miller, and Samuel A. Wickline, (1993), Quantification of Ultrasonic Anisotropy in Normal Myocardium with Lateral Gain Compensation of Two-Dimensional Integrated Backscatter Images, Ultrasound Med Biol, 19, 497–505PubMedCrossRefGoogle Scholar
  46. 46.
    Julio E. Perez, Steve C. Klein, David M. Prater, Carolyn E. Fraser, Hiram Cardona, Alan D. Waggoner, Mark R. Holland, James G. Miller, and Burton E. Sobel, (1992), Automated, On-Line Quantification of Left Ventricular Dimensions and Function By Echocardiography with Backscatter Imaging and Lateral Gain Compensation, Am J Cardiol, 70, 1200–1205PubMedCrossRefGoogle Scholar
  47. 47.
    Samuel A. Wickline, Edward D. Verdonk, and James G. Miller, (1991), Three-Dimensional Characterization of Human Ventricular Myofiber Architecture By Ultrasonic Backscatter, J Clin Invest, 88, 438–446PubMedCentralPubMedCrossRefGoogle Scholar
  48. 48.
    Samuel A. Wickline, Edward D. Verdonk, Andrew K. Wong, Richard K. Shepard, and James G. Miller, (1992), Structural Remodeling of Human Myocardial Tissue After Infarction, Circ, 85, 259–268CrossRefGoogle Scholar
  49. 49.
    Andrew K. Wong, Edward D. Verdonk, Brent K. Hoffmeister, James G. Miller, and Samuel A. Wickline, (1992), Detection of Unique Transmural Architecture of Human Idiopathic Cardiomyopathy By Ultrasonic Tissue Characterization, Circ, 86, 1108–1115CrossRefGoogle Scholar
  50. 50.
    James H. Rose, Mark R. Kaufmann, Samuel A. Wickline, Christopher S. Hall, James G. Miller, (1994), “A Proposed Microscopic Elastic Wave Theory for Ultrasonic Backscatter from Myocardial Tissue”, J Acoust Soc Am, J. H. Rose, M. R. Kaufmann, S.A. Wickline, C.H. Hall, James G. Miller, J Acoust Soc Am, 96, 1–13CrossRefGoogle Scholar
  51. 51.
    B.K. Hoffmeister, A.K. Wong, E.D. Verdonk, S.A. Wickline, and J.G. Miller, (1992), Anisotropy of Ultrasonic Backscatter from Human Tendon Compared to That from Normal Human Myocardium, .Proc. IEEE Ultrasonics Symposium, 91CH3079–1, 1127–1131Google Scholar
  52. 52.
    J.G. Miller, J.E. Perez, Jack G. Mottley, Eric I. Madaras, Patrick H. Johnston, Earl D. Blodgett, Lewis J. Thomas III, and B.E. Sobel, (1983), Myocardial Tissue Characterization: An Approach Based on Quantitative Backscatter and Attenuation, Proc. IEEE Ultrasonics Symposium, Atlanta, 83 CH 1947–1, 782–793Google Scholar
  53. 53.
    Lewis J. Thomas III, Benico Barzilai, Julio E. Perez, Burton E. Sobel, Samuel A. Wickline, and James G. Miller, (1989), Quantitative Real-Time Imaging of Myocardium Based on Ultrasonic Integrated Backscatter, IEEE Trans Ultrason Ferroelec FYeq Contr, UFFC-36, 466–470Google Scholar
  54. 54.
    Edward D. Verdonk, S. A. Wickline, and J. G. Miller, (1990), Quantification of the Anisotropy of Ultrasonic Quasi-Longitudinal Velocity in Normal Human and Canine Myocardium With Comparison to Anisotropy of Integrated Backscatter, Proc. IEEE Ultrasonics Symposium, 1990, Honolulu, 90CH2938–9, 1349–1352Google Scholar

Copyright information

© Springer Japan 1996

Authors and Affiliations

  • J. G. Miller

There are no affiliations available

Personalised recommendations