Development of the ventricular septum of the heart

  • Lodewyk H. S. Van Mierop
  • Lynn M. Kutsche


In man, development of the cardiovascular system begins in embryos of about 3 weeks ovulation age and is essentially completed 3 weeks later. Cardiovascular development, therefore, takes place very early and proceeds rapidly. This is a major reason why the study of cardiovascular development is difficult. Events of major importance for the understanding of the processes which lead to cardiac septation and the formation of atrio-ventricular and arterial valves take place so quickly and are so elusive that we still don’t have a thorough understanding of what exactly happens. These uncertainties continue to fuel controversies concerning not only normal cardiovascular development but also the pathogenesis of congenital cardiac defects. Considerable progress, however, has been made in the past few decades [1–9] and the blanks in our knowledge and understanding of heart development are becoming fewer and smaller.


Ventricular Septum Truncus Arteriosus Endocardial Cushion Atrioventricular Canal Septum Primum 
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  1. 1.
    Van Mierop LHS, Alley RD, Kausel HW, Stranahan A (1963) Pathogenesis of transposition complexes. I. Embryology of the ventricles and great arteries. Am J Cardiol 12. 216–225CrossRefGoogle Scholar
  2. 2.
    Asami I (1969) Beitrag zur Entwicklungsgeschichte des Kammerseptums im menschlichen Herzen mit besonderer Berücksichtigung der sogenannten Bulbusdrehung. Z Anat Entwicklgesch 128: 1–17CrossRefGoogle Scholar
  3. 3.
    Goor DA, Edwards JE, Lillehei CW (1970) The development of the interventricular septum of the human heart, correlative morphogenetic study. Chest 58: 453–467PubMedCrossRefGoogle Scholar
  4. 4.
    Anderson RH, Wilkinson JL, Arnold R, Lubkiewicz K (1974) Morphogenesis of bulboventricular malformations. I. Considerations of embryogenesis in the normal heart. Br Heart J 36: 242–255PubMedCrossRefGoogle Scholar
  5. 5.
    Van Mierop LHS (1979) Morphological development of the heart. In: Berne RM (ed) Handbook of physiology. Am Physiol Soc, Bethesda, pp 1–28Google Scholar
  6. 6.
    Steding G, Seidle W (1980) Contribution to the development of the heart. Part I: Normal development. Thorac Cardiovasc Surg 28: 386–409PubMedCrossRefGoogle Scholar
  7. 7.
    Wenink ACG (1981) Development of the ventricular septum. In: Wenink ACG, Oppenheimer-Dekker A, Moulaert AJ (eds) The ventricular septum of the heart. Nijhoff, The Hague, pp 23–34CrossRefGoogle Scholar
  8. 8.
    Wenink ACG (1981) Embryology of the ventricular septum. Separate origin of its components. Virchows Arch [A] 390: 71–79CrossRefGoogle Scholar
  9. 9.
    De la Cruz MV, Gimenez-Ribotta M, Saravalli O, Cayre R (1983) The contribution of the inferior endocardial cushion of the atrioventricular canal to cardiac septation and to the development of the atrioventricular valves: Study in the chick embryo. Am J Anat 166: 63–72PubMedCrossRefGoogle Scholar
  10. 10.
    Grant RP (1962) Embryology of ventricular flow pathways in man. Circulation 25: 756–779PubMedCrossRefGoogle Scholar
  11. 11.
    Davis CL (1924) The cardiac jelly of the chick embryo. Anat Rec 27: 201–202Google Scholar
  12. 12.
    Van Mierop LHS, Kutsche LM (1981) Comparative anatomy of the ventricular septum. In: Wenink ACG, Oppenheimer-Dekker A, Moulaert AJ (eds) The ventricular septum of the heart. Nijhoff, The Hague, pp 35–46CrossRefGoogle Scholar
  13. 13.
    Moulaert AJ, Oppenheimer-Dekker A (1976) Anterolateral muscle bundle of the left ventricle, bulboventricular flange and subaortic stenosis. Am J Cardiol 37: 78–81PubMedCrossRefGoogle Scholar
  14. 14.
    Van Mierop LHS (1979) Embryology of the univentricular heart. Herz 4: 78–85PubMedGoogle Scholar
  15. 15.
    Gittenberger-de Groot AC, Wenink ACG (1981) The ventricular septum in hearts with a stradding tricuspid valve. In: Wenink ACG, Oppenheimer-Dekker A, Moulaert AJ (eds) The ventricular septum of the heart. Nijhoff, The Hague, pp 175–183CrossRefGoogle Scholar

Copyright information

© Springer Japan 1986

Authors and Affiliations

  • Lodewyk H. S. Van Mierop
    • 1
  • Lynn M. Kutsche
  1. 1.Department of Pediatrics, Division of Cardiology and ResearchUniversity of Florida College of MedicineGainesvilleUSA

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