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Role of Alpha-adrenoceptor Activity in Regulation of Coronary Blood Flow During Myocardial Ischemia

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Regulation of Coronary Blood Flow

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Summary

We discuss the beneficial roles of alpha-adreno-ceptor activity on the pathogenesis of ischemic heart disease. The major effect of alpha-adrenoceptor stimulation in the coronary arteries was thought to be vasoconstriction, which may restrict myocardial oxygen supply and worsen myocardial ischemia. However, this is not necessarily true, because (1) alpha1-adrenoceptor stimulation favorably maintains endocardial coronary flow at the expense of epicardial flow reduction, (2) alpha1-adrenoceptor stimulation enhances the release of adenosine, and alpha2-adrenoceptor stimulation increases the release of EDRF and histamine, and (3) alpha2-adrenoceptor stimulation increases the sensitivity of the effects of adenosine. These beneficial effects of alpha-adrenoceptor stimulation may conversely attenuate the severity of myocardial ischemia and reperfusion injuries. Further clinical studies are necessary for better understanding of the roles of alpha-adrenoceptor activity in coronary flow regulation and myocardial function in human ischemic hearts.

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Authors and Affiliations

  1. The First Department of Medicine, Osaka University School of Medicine, Osaka, 553, Japan

    Takenobu Kamada

  2. Department of Medical Information Sciences, Osaka University Hospital, Osaka, 553, Japan

    Michitoshi Inoue

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  1. Masatsugu Hori
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  2. Masafumi Kitakaze
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  3. Akira Kitabatake
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  4. Takenobu Kamada
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  5. Michitoshi Inoue
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Editor information

Editors and Affiliations

  1. Department of Medical Information Sciences, Osaka University Hospital, Osaka, 553, Japan

    Michitoshi Inoue M.D., Ph.D. (Professor) (Professor)

  2. The First Department of Medicine, Osaka University School of Medicine, Osaka, 553, Japan

    Masatsugu Hori M.D., Ph.D. (Assistant Professor) (Assistant Professor)

  3. Department of Pharmacology, Niigata University School of Medicine, Niigata, 951, Japan

    Shoichi Imai M.D., Ph.D. (Professor) (Professor)

  4. Department of Physiology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA

    Robert M. Berne M.D. (Alumni Professor) (Alumni Professor)

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© 1991 Springer Japan

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Hori, M., Kitakaze, M., Kitabatake, A., Kamada, T., Inoue, M. (1991). Role of Alpha-adrenoceptor Activity in Regulation of Coronary Blood Flow During Myocardial Ischemia. In: Inoue, M., Hori, M., Imai, S., Berne, R.M. (eds) Regulation of Coronary Blood Flow. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68367-4_6

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  • DOI: https://doi.org/10.1007/978-4-431-68367-4_6

  • Publisher Name: Springer, Tokyo

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