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Regulation of Coronary Blood Flow pp 280–290Cite as

Complement-Induced Myocardial Ischemia: Neutrophil and Vascular Mechanisms

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Abstract

Medical therapy for acute myocardial infarction is currently directed at preventing acute arrhythmia, limiting the extent of necrosis, and preventing ventricular dilation. Experimental studies dealing with constraining the extent of necrosis in acute coronary occlusion have had limited success in the absence of reperfusion. Restoration of blood flow was found to be by far the most effective mechanism of reducing the degree of necrosis during acute myocardial infarction. Studies in experimental animals indicate that reperfusion within 2–3 h of coronary occlusion in canine hearts results in significant salvage of tissue, defined as the restoration of contractile function to tissue which would have otherwise developed into necrosis. Thus, in the 1980s, attempts to limit injury during acute myocardial infarction are primarily directed at reperfusion. It should be noted, however, that other measures, such as the administration of beta-adrenergic blocking agents, are effective in reducing mortality and perhaps morbidity and should not be neglected.

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Author information

Authors and Affiliations

  1. VA Medical Center, Research Service (151), San Diego, CA, 92161, USA

    Bruce R. Ito

Authors
  1. Robert L. Engler
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  2. Ughetta del Balzo
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  3. Bruce R. Ito
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Editor information

Editors and Affiliations

  1. Department of Medical Information Sciences, Osaka University Hospital, Osaka, 553, Japan

    Michitoshi Inoue M.D., Ph.D. (Professor) (Professor)

  2. The First Department of Medicine, Osaka University School of Medicine, Osaka, 553, Japan

    Masatsugu Hori M.D., Ph.D. (Assistant Professor) (Assistant Professor)

  3. Department of Pharmacology, Niigata University School of Medicine, Niigata, 951, Japan

    Shoichi Imai M.D., Ph.D. (Professor) (Professor)

  4. Department of Physiology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA

    Robert M. Berne M.D. (Alumni Professor) (Alumni Professor)

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© 1991 Springer Japan

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Engler, R.L., del Balzo, U., Ito, B.R. (1991). Complement-Induced Myocardial Ischemia: Neutrophil and Vascular Mechanisms. In: Inoue, M., Hori, M., Imai, S., Berne, R.M. (eds) Regulation of Coronary Blood Flow. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68367-4_24

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  • DOI: https://doi.org/10.1007/978-4-431-68367-4_24

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68369-8

  • Online ISBN: 978-4-431-68367-4

  • eBook Packages: Springer Book Archive

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