Coronary Blood Flow in Reperfused Myocardium

  • Thomas Aversano


The factors which determine coronary blood flow in myocardium subjected to ischemia and reperfusion are numerous, complex, and interrelated. They can be conveniently, if arbitrarily, divided into three broad categories. First, cellular and protein elements of the coronary perfustate, such as the leukocyte and fibrinogen, may affect coronary blood flow through effects on the microvasculature and on blood rheological properties, respectively. Second, the coronary conduit itself, the blood vessel, can also be affected by ischemia and reperfusion, particularly in its endothelial component and the associated vascular responses. Finally, the environment in which the coronary vessel finds itself, determined by characteristics of the myocyte and the interstitial space, can affect coronary flow by itself being profoundly changed after ischemia and reperfusion. While ischemia and reperfusion affects all three of these major determinants of coronary blood flow, whether or not coronary blood flow responses following reperfusion have a role in producing myonecrosis is unclear at this time.


Coronary Flow Blood Viscosity Coronary Blood Flow Coronary Occlusion Flow Response 


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Copyright information

© Springer Japan 1991

Authors and Affiliations

  • Thomas Aversano
    • 1
  1. 1.Johns Hopkins Medical InsititutionsBaltimoreUSA

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