Preoperative Chemotherapy for the Treatment of Osteosarcoma

  • Hideki Hamada
  • Yoshitaka Shinto
  • Takafumi Ueda
  • Hideki Yoshikawa
  • Atsumasa Uchida
  • Keiro Ono
Conference paper


At present, preoperative chemotherapy preceding limb-salvage surgery, is indispensable therapy for patients with osteosarcoma, in addition to being the most important prognostic factor. The aims of preoperative chemotherapy are (1) to control micrometastasis, (2) to control the primary tumor, and (3) to assess the effectiveness of the drugs used by grading of primary tumor necrosis.


Pulmonary Metastasis Preoperative Chemotherapy Poor Responder Necrosis Rate Parosteal Osteosarcoma 
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  1. 1.
    Bacci G, Picci P, Ruggieri P, Mercuri M, Avella M, Capanna R, Brach Del Prever A, Mancini A, Gherlinzoni F, Padovani G, Leonessa C, Biagini R, Ferraro A, Ferruzzi A, Cazzola A, Manfrini M, Campanacci M (1990) Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for osteosarcoma of the extremities. Cancer 65: 2539–2553PubMedCrossRefGoogle Scholar
  2. 2.
    Rosen G, Caparros B, Huvos AG, Kosloff C, Nirenberg A, Cacavio A, Marcove RC, Lane JM, Mehta B, Urban C (1982) Preoperative chemotherapy for osteogenic sarcoma: Selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer 49: 1221–1230PubMedCrossRefGoogle Scholar
  3. 3.
    Goldie JH, Coldman AJ (1979) A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate. Cancer Treat Rep 63: 1727–1733PubMedGoogle Scholar
  4. 4.
    Winker K, Beron G, Delling G, Heise U, Kabisch H, Purfurst C, Berger J, Jurgens H, Gerin V, Graf N, Russe W, Gruemayer ER, Ertelt W, Kotz R, Preusser P, Prindull G, Brandeis W, Landbeck G (1988) Neoadjuvant chomotherapy of osteosarcoma: Results of randomized co-operative trial (COSS-82) with salvage chemotherapy based on histological tumor response. J Clin Oncol 6: 329–337Google Scholar
  5. 5.
    Provisor A, Nachman J, Krailo M, Ettinger L, Hammond D (1987) Treatment of non-metastatic osteogenic sarcoma (os) of the exremities with pre-and postoperative chemotherapy. Proc Am Soc Clin Oncol 6: 217Google Scholar
  6. 6.
    Rosen G (1988) The current management of malignant bone tumours: Where do we go from here? Med J Aust 148: 373–377PubMedGoogle Scholar
  7. 7.
    Eilber FR, Mirra JJ, Grant TT, Weisenburger T, Morton DL (1980) Is amputation necessary for sarcoma?: A seven-year experience with limb salvage. Ann Surg 192: 431–438PubMedCrossRefGoogle Scholar
  8. 8.
    Rosen G (1986) Neoadjuvant chemotherapy for osteogenic sarcoma: A model for the treatment of other highly malignant neoplasms. Recent Results Cancer Res 103: 148–157PubMedCrossRefGoogle Scholar
  9. 9.
    Picci P, Bacci G, Campanacci M, Gasparini M, Pilotti S, Cerasoli S, Bertoni F, Guerra A, Capanna R, Albisinni U, Galletti S, Gherlinzoni F, Calderoni P, Sudanese A, Baldini N, Bernini M, Jaffe N (1985) Histologic evaluation of necrosis in osteosarcoma induced by chemotherapy. Cancer 56: 1515–1521PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 1992

Authors and Affiliations

  • Hideki Hamada
    • 1
  • Yoshitaka Shinto
  • Takafumi Ueda
  • Hideki Yoshikawa
  • Atsumasa Uchida
  • Keiro Ono
    • 2
  1. 1.Department of Orthopaedic SurgeryOsaka Prefectural HospitalSumiyoshi, Osaka, 558Japan
  2. 2.Department of Orthopaedic SurgeryOsaka University Medical SchoolOsaka, 553Japan

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